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Bis-o-vanillin ethylene diamine schiff base and transitional metal coordination compound and preparation method thereof

A technology of vanillin ethylenediamine, Schiff's base cadmium, and vanillin ethylenediamine, which is applied in the field of medicine, can solve problems such as no public reports, and achieve the effect of simple preparation method

Inactive Publication Date: 2013-05-08
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of di-ortho-vanillin ethylenediamine Schiffer base in combination with transition metals as a ligand to prepare complexes in diabetes medicines has not been publicly reported so far.

Method used

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  • Bis-o-vanillin ethylene diamine schiff base and transitional metal coordination compound and preparation method thereof
  • Bis-o-vanillin ethylene diamine schiff base and transitional metal coordination compound and preparation method thereof
  • Bis-o-vanillin ethylene diamine schiff base and transitional metal coordination compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, taking transition metal copper (Cu) as example, its molecular formula is {[Cu(C 18 h 18 N 2 o 4 )](NO 3 )(H 2 O)} complex preparation method is:

[0020] 0.0048g (0.02mmol) of Cu(NO 3 ) 2 Solid and 0.0075g (0.02mmol) of bis-o-vanillin ethylenediamine Schiff's base were placed in two clean vials respectively, 3mL and 5mL of methanol were added to dissolve it, and then the bis-o-vanillin The solution of ethylenediamine Schiffer's base was added dropwise to Cu(NO 3 ) 2 In the solution, after stirring evenly with a glass rod, filter the mixture into another clean vial, dilute it to 8mL with methanol, and let it stand at 18-25°C. The complex crystals will precipitate in 10-14 days, and the yield is 23 %. Infrared spectrum (KBr pellet, cm -1 ): 3436; 1636; 1385; 985; 740. UV-Vis absorption spectrum (in methanol), λmax / nm: 233.

Embodiment 2

[0021] Embodiment 2, taking vanadium as example, molecular structural formula is {[V (C 18 h 18 N 2 o 4 )(CH 3 OH)(H 2 O)](H 2 O)} complex preparation method is:

[0022] Place 0.0075g (0.02mol) of bis-o-vanillin ethylenediamine Schiff's base in a vial, drop into 0.5mL N,N-dimethylformamide to dissolve it, then add 3mL of methanol; weigh 0.0032g (0.02mol) VOSO 4Put it in a vial, add 0.5mL N,N-dimethylformamide and heat to dissolve, then add 3mL methanol; then mix the two solutions, stir well, filter, and dilute the filtrate to 8mL with methanol, at 18-25℃ After standing still, crystals are formed in 10-14 days, and the yield is 30%. The melting point is 236-238°C. Infrared spectrum (KBr pellet, cm-1): 1591; 2929; 1440; 1302; 1246. UV-Vis absorption spectrum (in methanol), λmax / nm: 228.4; 294.3.

Embodiment 3

[0023] Embodiment 3, taking cadmium as example, molecular formula is [Cd 3 (C 18 h 18 N 2 o 4 ) 2 I 2 ] The compound preparation method is:

[0024] Accurately weigh 0.0075g (0.02mol) of bis-o-vanillin ethylenediamine Schiff's base in a vial, drop into 0.5mL N,N-dimethylformamide to dissolve it, and then add 3mL of methanol ; Weigh 0.0110g (0.03mol) CdI 2 Put it in a vial, add 0.5mL N,N-dimethylformamide and heat it to dissolve, then add 3mL methanol; then mix the two solutions, stir well, filter, dilute the filtrate to 8mL with methanol, in 18-25 After standing at ℃, pale yellow crystals are formed in 20-25 days, and the yield is 47%.

[0025] The present invention is used for the inhibitory action to α-glucosidase, and the method for its inhibition rate measurement is:

[0026] Take 4 plastic test tubes, add 1ml tris hydrochloric acid buffer solution of pH=7.20 and 1ml 10mmol L -1 The α-glucosidase (4-nitrophenyl-α-D-glucopyranosidase), the addition of other reagen...

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Abstract

The invention relates to a bis-o-vanillin ethylene diamine schiff base and transitional metal coordination compound and a preparation method thereof, which can solve the problem of the application of a coordination compound prepared by compounding bis-o-vanillin ethylene diamine schiff base serving as a ligand and a transitional metal to a medicament for treating diabetes. The coordination compound is the bis-o-vanillin ethylene diamine schiff base and transitional metal coordination compound prepared by compounding the bis-o-vanillin ethylene diamine schiff base with the transitional metal. The preparation method of the coordination compound comprises the following steps of: dissolving one of 0.02 to 0.03mol of transitional metal vanadium, 0.02 to 0.03mol of cadmium salt or 0.02 to 0.03mol of copper salt and 0.02mol of bis-o-vanillin ethylene diamine schiff base by using 3 to 5mL of methanol or mixed solution of 3 to 5mL of methanol and N,N-dimethyl formamide in the volume ratio of 1:6 respectively; slowly and uniformly mixing; filtering the mixed liquor; diluting the obtained filtrate to 8mL by using methanol; and standing at the temperature of between 18 and 25 DEG C for 5 to 30 days to obtain the coordination compound. The coordination compound has a simple preparation method, can be effectively used for preparing the medicament for treating the diabetes and is an innovation of the medicament for treating the diabetes.

Description

1. Technical field [0001] The invention relates to the field of medicine, in particular to a class of o-vanillin Schiff base transition metal complexes and a bis-vanillin ethylenediamine Schiff base transition metal complex potentially applied in diabetes medicines and a preparation method thereof . 2. Background technology [0002] Diabetes cannot be cured at present, and it is necessary to take medicine for life to control blood sugar. For a long time, blood glucose monitoring in the course of diabetes treatment has often only paid attention to fasting blood glucose, but recent studies have found that postprandial hyperglycemia has an important impact on the occurrence of diabetic macrovascular complications, especially cardiovascular and cerebrovascular complications, and the latter It is the leading cause of death from diabetes. In the course of the onset, postprandial hyperglycemia often occurs first, and then develops into diabetes, that is, the former is the early s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F1/08C07F3/08C07F9/00A61K31/30A61K31/28A61P3/10
Inventor 杨怀霞刘艳菊李玉贤王霞苑娟付显娇
Owner HENAN UNIV OF CHINESE MEDICINE
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