Lipid preparation containing radix gentianae totalglycoside-phospholipid complexes and preparation method thereof
A technology of total glycoside phospholipids and complexes, which is applied in the field of lipid preparations containing gentioside phospholipid complexes and its preparation. Difficult to disperse and other issues, to achieve the effect of enhancing pharmacological effects and clinical efficacy, improving bioavailability, improving stability and transmembrane transport ability
Inactive Publication Date: 2011-06-08
FUDAN UNIV
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AI Technical Summary
Problems solved by technology
However, phospholipid complexes still have the following problems in practical applications: first, the combination of water-soluble drugs and phospholipids is not stable, and they are easily dissociated in gastrointestinal fluid; second, due to the high viscosity of phospholipids, the formed phospholipids The complex is easy to form agglomerates in the gastrointestinal fluid, and it is difficult to spread, disperse and penetrate the gastrointestinal biofilm in the gastrointestinal tract; the third is that the phospholipid complex is difficult to disperse in common preparations due to its strong hydrophobicity
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0033] Weigh 1 g of the gentioside phospholipid complex, add it to 10 g of medium-chain fatty acid glycerides, stir until a transparent solution is formed, and obtain an oil solution composition of the phospholipid complex.
Embodiment 2
[0035] Weigh 1 g of gentioside phospholipid complex, add 5 g of medium-chain fatty acid glycerides and 2 g of Imwitor 742, stir until a transparent solution is formed, and obtain an oil solution composition of phospholipid complex.
Embodiment 3
[0037] Weigh 1 g of gentioside phospholipid complex, add 10 g of medium-chain fatty acid glycerides and 5 g of PLUROLOLEIQUE CC 497, stir until a transparent solution is formed, and obtain an oil solution composition of phospholipid complex.
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Abstract
The invention belongs to the pharmacy field of traditional Chinese medicine and relates to a lipid preparation containing radix gentianae totalglycoside-phospholipid complexes and a preparation method thereof. The lipid preparation of the invention is formed by dissolving phospholipid complexes (which are formed by phospholipids and radix gentianae totalglycosides, which is the effective part of the traditional Chinese medicine) in one or a plurality of middle chain or long chain aliphatic acid glyceride(s) or in an oil phase with amphiphilic surfactants added thereto to prepare an oil solution composition; or dissolving the phospholipid complexes in a mixed solution which contains a certain proportion of surfactant, co-surfactant and oil phase to prepare a self-microemulsifying composition. The composition of the invention can substantially raise the capability of the radix gentianae totalglycoside-phospholipid complexes to penetrate biomembrane and enhance the biological availability of the radix gentianae totalglycosides.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a lipid preparation containing gentioside phospholipid complex and a preparation method thereof Background technique [0002] The prior art discloses that gentian glycosides are the effective parts of water-soluble split iridoid glycosides obtained by separating and purifying commonly used Chinese medicinal materials Radix Et Rhizoma Gentianae and Radix Gentianae Macrophyllae, and its active ingredients include Gentiopicroside, dangyaoside, dangyaopicroside, picrogentioside, picroside, etc. Among them, gentiopicroside has the highest content and the strongest activity. Studies have shown that gentiopicroside has significant anti-liver damage, anti-virus, and anti-inflammatory effects, and has important development value. However, because gentiopicroside has strong water solubility and poor transmembrane transport performance, it is difficult to penetrate the ga...
Claims
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IPC IPC(8): A61K36/515A61K47/48A61K9/48A61K9/16A61K9/20A61K47/14A61K47/32A61K47/34A61P1/16A61P31/12A61P29/00A61K47/10A61K47/26A61K47/44A61K47/54
Inventor 王建新韩丽妹施雯秦晶沈鸣
Owner FUDAN UNIV
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