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Vegetal shell of soft capsule

A plant-based, soft capsule technology, applied in capsule delivery, medical preparations of non-active ingredients, inorganic non-effective ingredients, etc., can solve the problem of soft capsules not being soft, good softness, and gelatin soft capsules that cannot meet the different needs of consumers and other problems, to achieve the effect of high transparency and good softness

Active Publication Date: 2012-07-25
SIRIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Soft capsules have become one of the most widely used pharmaceutical preparations since their introduction in 1935, especially in recent decades, they have gradually become the "carrier" of health food and health products; at present, the rubber of soft capsules is made of cows, pigs and other animals. Gelatin extracted from bone or skin and other materials is used as raw material, and glycerin, sorbitol, etc. are added to make it. Although gelatin has good characteristics when preparing soft capsules, the gelatin soft capsules produced cannot meet the requirements due to the characteristics of gelatin itself. Different needs of consumers for products
[0003] 1) The use of animal protein in gelatin may cause environmental pollution;
[0004] 2) The tolerance of gelatin to temperature and humidity is relatively strict, and it is easy to stick, deform and leak oil during transportation and storage, so its application is limited;
[0005] 3) The capsule shell of gelatin soft capsules is easy to age, resulting in prolonged disintegration time of the product within the validity period;
[0006] 4) Gelatin is derived from animals and is not suitable for vegetarians, which restricts the promotion and application of soft capsule products in health care products, food and medicine
For example, Chinese patent CN101637610A discloses a plant-based soft capsule and its manufacturing process, but the capsule shell of the soft capsule is not soft enough, and the capsule skin has poor transparency, and the appearance appears cloudy, dull, and unattractive to consumers; U.S. Patent No. 6,582,727 discloses the plant-based capsule shell formula to produce soft capsules, which are not soft and have too high strength. During storage and transportation, the capsule skin is prone to rupture and the product leaks oil.
[0008] In summary, the vegetable shells of current soft capsules are either good in transparency and poor in softness or good in softness and high in transparency.

Method used

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  • Vegetal shell of soft capsule
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  • Vegetal shell of soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A vegetable shell of a soft capsule, which comprises the following raw materials in parts by weight:

[0046] 4 parts of carrageenan, 25 parts of starch, 25 parts of glycerin, 1 part of dipotassium hydrogen phosphate, 5 parts of water;

[0047] Vegetable capsule shells can be prepared through the existing mode of producing capsule shells of soft capsules.

[0048] Transparency and softness of embodiment 1 product are evaluated by the above-mentioned method, and the results are shown in table 5:

[0049] table 5.

[0050]

[0051] The soft capsule shell transparency that embodiment 1 produces is obviously better than contrast 1 and contrast 2, and softness is better than contrast 1 and contrast 2, so this formula has unexpected technical effect.

Embodiment 2

[0053] A vegetable shell of a soft capsule, which comprises the following raw materials in parts by weight:

[0054] 10 parts of carrageenan, 65 parts of dextrin, 50 parts of glycerin, 2 parts of dipotassium hydrogen phosphate, 20 parts of water;

[0055] Vegetable capsule shells can be prepared through the existing mode of producing capsule shells of soft capsules.

[0056] Transparency and softness of the product of Example 2 are evaluated as described above, and the results are shown in Table 6:

[0057] Table 6.

[0058]

[0059] The soft capsule shell transparency that embodiment 2 produces is slightly better than contrast 2, but obvious softness is better than contrast 1 and contrast 2, so this formula has unexpected technical effect.

Embodiment 3

[0061] A vegetable shell of a soft capsule, which comprises the following raw materials in parts by weight:

[0062] 7 parts carrageenan, 45 parts starch, 40 parts sorbitol, 1.5 parts potassium dihydrogen phosphate, 12 parts water;

[0063] Vegetable capsule shells can be prepared through the existing mode of producing capsule shells of soft capsules.

[0064] Transparency and softness of the product of Example 3 are evaluated as described above, and the results are shown in Table 7:

[0065] Table 7.

[0066]

[0067] The soft capsule shell transparency that embodiment 3 produces is obviously better than contrast 1 and contrast 2, and softness is better than contrast 1 and contrast 2, so this formula has unexpected technical effect.

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Abstract

The invention discloses a vegetal shell of a soft capsule, comprising the following raw materials in parts by weight; 4-10 parts of carrageenin, 25-65 parts of one or mixture of starch and dextrin with any proportions, 25-50 parts of one or mixture of glycerin and sorbitol with any proportions, 1-2 parts of one or mixture of potassium acid phosphate and monopotassium phosphate with any proportions, and 5-20 parts of water. The vegetal shell of the soft capsule, disclosed by the invention, has high brightness and also has the advantage of excellent softness.

Description

technical field [0001] The invention relates to a soft capsule, in particular to a vegetable shell of the soft capsule. The vegetable capsule produced by the invention can be used in the production of soft capsule preparations in the fields of food, health products, and medicine. Background technique [0002] Soft capsules have become one of the most widely used pharmaceutical preparations since their introduction in 1935, especially in recent decades, they have gradually become the "carrier" of health food and health products; at present, the rubber of soft capsules is made of cows, pigs and other animals. Gelatin extracted from bone or skin and other materials is used as raw material, and glycerin, sorbitol, etc. are added to make it. Although gelatin has good characteristics when preparing soft capsules, the gelatin soft capsules produced cannot meet the requirements due to the characteristics of gelatin itself. Different needs of consumers for products [0003] 1) The ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K47/10A61K47/36A61K9/48
Inventor 陈琼张志勇李绪发方素琼
Owner SIRIO PHARMA CO LTD