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Novel medicinal application of baicalein

A technology for baicalein and new uses, applied in the field of new medical uses of baicalein, can solve the problems of demyelinating diseases without specific treatment methods, etc., achieve good prospects and economic benefits, the dosage of administration is beneficial to control, and the mechanism of action clear effect

Inactive Publication Date: 2011-06-29
SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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  • Abstract
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Problems solved by technology

[0004] There are currently no specific treatments for demyelinating diseases

Method used

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  • Novel medicinal application of baicalein
  • Novel medicinal application of baicalein
  • Novel medicinal application of baicalein

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Embodiment Construction

[0025] The specific implementation of the technical solution of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0026] Source of baicalein: baicalein was purchased from Sigma-Aldrich, USA, product number 465119, purity 98%, molecular formula C 15 h 10 o 5 , relative molecular mass 270.24.

[0027] 1. The relieving effect of baicalein on experimental allergic cerebrospinal meningitis in mice

[0028] Experimental C57BL / 6 mice were bred in the barrier system of the Experimental Animal Center of Shanghai Jiao Tong University School of Medicine. The 6-8 week old mice were randomly divided into groups and immunized with MOG to establish experimental autoimmune encephalomyelitis (EAE) animal models. From the 7th day of modeling, that is, the early stage of the disease, 50 mg / ml BA was administered intraperitoneally to the BA preventive treatment group every day, and the solvent control was given to the control group intrap...

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Abstract

The invention discloses novel medicinal application of baicalein, in particular to application of the baicalein to the preparation of medicament for treating demyelinative diseases of central nervous system. The baicalein shows favorable treatment functions on an experimental allergic cerebrospinal meningitis model of a mouse and the treatment functions are achieved by inhibiting microglia 12 / 15 lipoxygenase in the central nervous system and adjusting the expression condition of a group of molecules with nerve protecting functions, such as FIZZ1 (foundininflammatoryzone1), MRC1 (mannose receptor, C type 1) and Arg1 (arginase 1) on the mRNA (messenger ribonucleic acid) level, thereby inducing high-level M2 type microglia in the central nervous system. The M2 type microglia has the function of CNS (central nervous system) neuroendocrine nutrilit and can promote the repair of medullary sheath, thereby relieving the progress of disease conditions.

Description

【Technical field】 [0001] The invention relates to the technical field of medicine, and more specifically relates to a new medicine application of baicalein. 【Background technique】 [0002] Demyelination is a disease in which the myelin sheath is lost or thinned. Myelin provides a high-impedance, low-capacitance insulating environment for nerve electrical signal transmission between Ranvier's junctions, where action potentials are generated. The conduction of nerve impulses is carried out by jumping in the adjacent Ranvier node, and it is discontinuous. This conduction mode makes the conduction of nerve impulses with a small energy cost and a high safety factor. Therefore, demyelination can cause significant conduction abnormalities, and after demyelination can also cause abnormal electrical activity. [0003] This abnormality mainly includes two categories: (1) negative signs: such as weakness, decreased or lost sensation, and decreased tendon reflexes, mostly caused by sl...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P25/00A61P25/28A61P43/00
Inventor 张雁云徐经纬肖意传
Owner SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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