Water-soluble coenzyme Q 10 compound and preparation method thereof

A complex, water-soluble technology, applied in the field of water-soluble coenzyme Q10 complex and its preparation, to achieve the effect of improving solubility
CN102127172BInactive Publication Date: 2012-10-10YUNNAN NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
YUNNAN NORMAL UNIV
Publication Date
2012-10-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a water-soluble coenzyme Q10 compound and a preparation method thereof, belonging to the technical field of fine chemical industry. The product is a compound of mono-[6-dithylenetriamine]-6-deoxizing]-beta-cyclodextrin and coenzyme Q10. The preparation method comprises the following steps of: (1) dissolving the coenzyme Q10 in tetrahydrofuran, adding the obtained solutionto a mono-[6-dithylenetriamine]-6-deoxizing]-beta-cyclodextrin water solution, and stirring for 2-4 days at 20-40 DEG C for reacting, wherein the molar ratio of the poured coenzyme Q10 to the poured mono-[6-dithylenetriamine]-6-deoxizing]-beta-cyclodextrin is 1: 1-1: 3; and (2) evaporating to remove the tetrahydrofuran, filtering to remove the coenzyme Q10 which does not participate in inclusion,evaporating the obtained filtrate to dryness to obtain crystals and drying in vacuum. In the invention, a solid compound obtained through preparing by adopting a supermolecular method and separating can rapidly dissolve in water so that the water solubility of the coenzyme Q10 is improved to 1.52mg / mL from the original 8.0*10-5mg / mL, with 19,000 times of solubilization. The compound prepared by adopting the preparation method disclosed by the invention can be used as a substitute of the coenzyme Q10 to be applied to clinic, and a new water-soluble controlled-release compound is provided for clinical trial of the coenzyme Q10.
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Description

technical field

[0001] The invention relates to a water-soluble coenzyme Q10 complex and a preparation method thereof, belonging to the technical field of fine chemicals, and in particular to the preparation of coenzymes by using mono-[6-(diethylenetriamine)-6-deoxy]-β-cyclodextrin functional molecules Water-soluble complex of Q10. The water-soluble coenzyme Q10 complex can solubilize and slow-release coenzyme Q10, thereby enhancing and prolonging the drug effect. Background technique

[0002] The structure of coenzyme Q10(1) is shown below, and its chemical name is 2,3-dimethoxy-5-methyl-6-decisopentenylbenzoquinone (2,3-Dimethoxy-5-methyl-6- decaprenyl-1,4-benzoquinone), is a quinone ring compound. In 1940, Moore et al. discovered that coenzyme Q10 is a kind of fat-soluble quinone compound with common characteristics with vitamins. It widely exists in the mitochondria of cells such as animals, plants, and microorganisms, and can transport electrons in various biological ...

Claims

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