Adding liquid for storing platelets under liquid low temperature condition and application thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI BLOOD CENT
- Publication Date
- 2013-10-09
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Abstract
Description
technical field
[0001] The invention relates to a preparation for preserving platelets, in particular to an additive solution for preserving platelets under liquid low temperature conditions. Background technique
[0002] Due to the significant risk of contamination by bacteria and other pathogens in the routine storage method of clinical platelets (shaking storage at 22°C), the current storage period of platelets is limited to 5 days. In addition, this condition also leads to the production of various cytokines, such as TGF-β, RANTES, IL-1β, and IL-8, by residual white blood cells in platelet products, which can cause non-hemolytic transfusion reactions and other transfusion side effects . At present, the methods to solve this problem mainly include contamination detection of platelet products, freezing or refrigerated storage, etc. However, previous studies have shown. Low-temperature refrigeration can lead to the activation and damage of platelets, and the platelets wi...