Adding liquid for storing platelets under liquid low temperature condition and application thereof
A technology of platelets and additive solution, which is applied in the fields of application, preservation of human or animal body, animal husbandry, etc., can solve the problems such as the advent of platelet refrigeration additive solution
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0035] Prepare platelet additive solution according to the formula in Table 1.
[0036] The preparation method is as follows: taking blood anticoagulant, platelet metabolism substrate, balance salt, and cold storage protection agent according to the formula, adding ion water, fully stirring and dissolving, and then filter sterilization or high-pressure steam sterilization.
[0037] Table 1 (unit mmol / L)
[0038] composition
Embodiment 2
[0040] Under aseptic conditions, each unit of apheresis platelet sample was divided into two parts, which were placed in special platelet storage bags, centrifuged (1000xg, 15min), and 35% of plasma was retained, and the refrigerated supplement solution 1 ( Contains trehalose and mannitol, the formula is shown in Table 2) and PAS-IIIM (SSP+, Macopharma Inc. has been clinically used for platelet storage at 22°C in Europe) platelet supplement solution, and stored at 4°C for 7 days.
[0041] Table 2.
[0042] composition
Concentration (mmoL / L)
Sodium chloride
69
[0043] sodium citrate
10
Sodium dihydrogen phosphate
26
Disodium phosphate
26
potassium chloride
5
magnesium chloride
1.5
sodium acetate
30
Trehalose
50
Mannitol
80
[0044] 1. Platelets were stored for 7 days, and samples were taken, and the platelet count and average platelet volume...
Embodiment 3
[0051] Under aseptic conditions, each unit of apheresis platelet sample was divided into two parts, which were placed in special platelet storage bags, centrifuged (1000xg, 15min), and 35% of plasma was retained, and the refrigerated supplement solution 2 ( Contains DMSO and mannitol, the formula is shown in Table 4) and PAS-IIIM (SSP+, Macopharma Inc. has been clinically used for platelet preservation at 22°C in Europe) platelet supplement solution, and stored at 4°C for 7 days.
[0052] Table 4.
[0053] composition
Prescription amount (mmoL / L)
Sodium chloride
69
sodium citrate
10
Sodium dihydrogen phosphate
26
Disodium phosphate
26
potassium chloride
5
magnesium chloride
1.5
sodium acetate
30
DMSO
5%
Mannitol
80
[0054] Platelets were stored for 7 days and samples were taken, and the platelet count and mean platelet volume were measured with a pla...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap