Oil-in-water type notopterygium oil nano emulsion oral liquid and preparation method thereof
An emulsion oral liquid, oil-in-water type technology, applied in the field of medicine, can solve the problems of difficult processing into injections and tablets, unstable physical properties, low bioavailability, etc., and achieves improved sensory quality, clear and transparent appearance, Simple preparation process
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Embodiment 1
[0047] Preparation:
[0048] 1) Weigh 3.75g of RH-40, 0.75g of absolute ethanol, 0.02g of oil phase vitamin E oil, 0.02g of notopterygium oil, and 5.46g of distilled water for later use;
[0049] 2) Mix RH-40 and absolute ethanol and stir well;
[0050] 3) Add the oil phase vitamin E oil into the solution prepared in step 2) and stir well;
[0051] 4) Add notopterygium oil to the solution prepared in step 3), stir well, and slowly add distilled water dropwise at 20°C to 25°C and stir well until a clear, transparent, low-viscosity and fluid yellow or colorless transparent O / The W-type nanoemulsion is the oil-in-water type notopterygium oil nanoemulsion oral liquid of the present invention.
Embodiment 2
[0053] Tween-80 3g, glycerin 1.5g, 1,2-propanediol 0.5g, liquid paraffin 0.3g, notopterygium oil 0.1g, distilled water 4.6g.
Embodiment 3
[0055] Tween-80 3g, absolute ethanol 1.5g, 1,2-propanediol 0.5g, isopropyl myristate 0.15g, notopterygium oil 0.15g, distilled water 4.7g.
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