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Application of fiveleaf gynostemma herb suspension and extract to preparation of drug for treating and resisting depression

An extract of Gynostemma pentaphyllum, antidepressant technology, applied in the field of medicine, can solve the problems of no experimental research on Gynostemma pentaphyllum, no application of antidepressant drugs, etc.

Inactive Publication Date: 2012-07-25
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there has been no report of Gynostemma pentaphyllum in antidepressant experimental research, nor has it been used as an antidepressant drug.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Given in the technical scheme of the above-mentioned content of the invention, the suspension is prepared by using coarse powder of rhizome of Gynostemma pentaphyllum root, suspended in distilled water, so that the suspension contains 1 g / mL of Gynostemma pentaphyllum in terms of crude drug.

Embodiment 2

[0011] Given in the technical scheme of above-mentioned content of the invention, described extract is:

[0012] A. Gynostemma pentaphyllum water extract: use Gynostemma pentaphyllum rhizome powder, add 10 mL water (W / V=1︰10) for every 1 g Gynostemma pentaphyllum powder, reflux extraction 3 times, 2 h each time, filter, combine filtrate, recover Water, so that the concentration of the medicinal solution is calculated as crude drug, containing 1 g / mL of Gynostemma pentaphyllum.

[0013] B. Gynostemma pentaphyllum 50% ethanol extract: use Gynostemma pentaphyllum rhizome powder, add 10 mL of 50% ethanol (W / V=1:10) for every 1 g of Gynostemma pentaphyllum powder, reflux extraction 3 times, 2 h each time, filter , combine the filtrates, recover the ethanol until there is no alcohol smell, and make the concentration of the medicinal solution calculated by crude drug, containing 1 g / mL of Gynostemma pentaphyllum.

[0014] C. Gynostemma 75% ethanol extract: use Gynostemma rhizome pow...

Embodiment 3

[0021] Given in the technical scheme of above-mentioned content of the invention, described pill, powder, dripping pill, tablet or capsule are a kind of, be to get Gynostemma pentaphyllum coarse powder 250 g, every 250 g add 2500 mL (W / V=1 ︰10) any solvent of water, 50%~95% ethanol, ethyl acetate, acetone or 120# gasoline, reflux extraction for 3 times, 2 hours each time, filter and combine the filtrate, recover the solvent to the extract, dry and pulverize , cross a 100-mesh sieve, add 12.5 g of magnesium stearate or starch, dextrin, mix well, and make pills, powders, dripping pills, tablets or capsules.

[0022] The applicant should point out that the above-mentioned embodiments should be understood as only for illustrating the present invention but not for limiting the protection scope of the present invention. After reading the contents of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalen...

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PUM

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Abstract

The invention relates to application of fiveleaf gynostemma herb suspension and extract to preparation of a drug for treating and resisting depression, wherein the problem on preventing and treating depression can be effectively solved. A technical scheme for solving the problem comprises the steps of: smashing Chinese medicinal fiveleaf gynostemma herb and adding water to prepare the suspension with a concentration equal to that the crude drug content is 1g / mL, or smashing the Chinese medicinal fiveleaf gynostemma herb and carrying out reflux extraction by utilizing one of water, 50%-95% ethanol, acetone, ethyl acetate and gasoline or petroleum ether according to a conventional method to prepare the extract. In the invention, the suspension or the extract made from the Chinese medicinal fiveleaf gynostemma herb is used for preparing the drug for treating and resisting the depression; and therefore, the problem on preventing and treating the depression is solved and the novel application of the fiveleaf gynostemma herb to prevention and treatment of the depression is opened up and is a great innovation in the traditional Chinese medicine.

Description

technical field [0001] The invention relates to the field of medicine, and is a new application of the antidepressant effect of the traditional Chinese medicine gynostemma pentaphyllum, in particular the application of a suspension and extract of gynostemma pentaphylla in the preparation of antidepressant drugs. Background technique [0002] Depression is a group of disorders characterized by marked and persistent low mood, rigid behavior, and pessimistic world-weariness. It's so common, in fact, that it's been called the "common cold" of mental illness, and it's also a serious, life-threatening illness that afflicts tens of millions of people around the world. Drugs currently used to treat depression mainly include tricyclic antidepressants (TCAs), monoamine oxidase (MAO) inhibitors, and 5-hydroxytryptamine (5-HT) reuptake inhibitors, but all have varying degrees of side effects, such as drowsiness , blurred vision, high blood pressure, convulsions and low libido, etc., th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/424A61P25/24A61K125/00
Inventor 王君明崔瑛
Owner HENAN UNIV OF CHINESE MEDICINE
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