Application of IL-17 inhibitor in preparing medicament for treating influenza

A technology of inhibitors and drugs, applied in gene therapy, antiviral agents, pharmaceutical formulations, etc., can solve the problems of high mutation rate and increased drug resistance of influenza virus

Active Publication Date: 2011-09-21
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although influenza treatment drugs are available as of now, there is still a need for new types of influenza treatment drugs due to the high mutation rate of influenza viruses and rising drug resistance

Method used

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  • Application of IL-17 inhibitor in preparing medicament for treating influenza
  • Application of IL-17 inhibitor in preparing medicament for treating influenza
  • Application of IL-17 inhibitor in preparing medicament for treating influenza

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Anti-IL-17 antibody can reduce the death of mice caused by influenza A H1N1 influenza virus BJ501 strain infection

[0033] Experimental Materials:

[0034] 1) Main experimental instruments: three-level biosafety laboratory, three-level biological safety cabinet, animal breeding cabinet, mouse breeding cage, small animal surgical instruments, sterile syringes, pipettes, pipettes, etc.

[0035] 2) Main experimental reagents: anti-IL-17A monoclonal antibody (AbM50016-1-PU, purchased from Beijing Huada Protein Research and Development Center Co., Ltd.), antibody control (AbM59530-10-PU, purchased from Beijing Huada Protein Research and Development Center Co., Ltd. company), 1% (W / V) pentobarbital sodium solution, virus dilution, disinfectant (2.5% iodine and 75% alcohol), etc.

[0036] 3) Virus: Influenza A H1N1 influenza virus BJ501 strain

[0037] http: / / www.ncbi.nlm.nih.gov / Taxonomy / Browser / wwwtax.cgi? mode=Info

[0038] &id=648856&lvl=3&keep=1&srchmod...

Embodiment 2

[0054] Example 2 Anti-IL-17A Antibody Relieves Pulmonary Edema in Mice After Influenza A H1N1 Influenza Virus BJ501 Strain Infection

[0055] Experimental Materials:

[0056] 1) Main experimental instruments: three-level biological safety laboratory, three-level biological safety cabinet, animal breeding cabinet, mouse breeding cage, small animal surgical instruments, high temperature tissue dryer, sterile syringe, pipette, pipette, etc. .

[0057] 2) Main experimental reagents: anti-IL-17A monoclonal antibody (AbM50016-1-PU, purchased from Beijing Huada Protein Research and Development Center Co., Ltd.), antibody control (AbM59530-10-PU, purchased from Beijing Huada Protein Research and Development Center Co., Ltd. company), 1% (W / V) pentobarbital sodium solution, virus diluent, sterile PBS, disinfectant (2.5% iodine and 75% alcohol), etc.

[0058] 3) Virus: Influenza A H1N1 influenza virus BJ501 strain

[0059] http: / / www.ncbi.nlm.nih.gov / Taxonomy / Browser / wwwtax.cgi? m...

Embodiment 3

[0077] Example 3 Anti-IL-17 Antibody Can Relieve Pathological Damage of Mouse Lung Histopathology Infected by Influenza A H1N1 Influenza Virus BJ501 Strain

[0078] Experimental Materials:

[0079] 1) Main experimental instruments: three-level biological safety laboratory, three-level biological safety cabinet, animal breeding cabinet, mouse breeding cage, small animal surgical equipment, vertical mixer, tissue slicer, tissue embedding machine, microscope, Bacterial syringes, pipettes, pipettes, etc.

[0080] 2) Main experimental reagents: anti-IL-17A monoclonal antibody (AbM50016-1-PU, purchased from Beijing Huada Protein Research and Development Center Co., Ltd.), antibody control (AbM59530-10-PU, purchased from Beijing Huada Protein Research and Development Center Co., Ltd. company), 1% (W / V) pentobarbital sodium solution, virus diluent, paraformaldehyde fixative, sterile PBS, disinfectant (2.5% iodine and 75% alcohol), etc.

[0081] 3) Virus: Influenza A H1N1 influenza v...

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Abstract

The invention relates to an application of an IL-17 inhibitor in preparing a medicament for treating influenza, in particular relating to an application of the IL-17 inhibitor in preparing a medicament for treating and / or preventing virus infection of influenza. The IL-17 inhibitor can be used for reducing or knocking out the expression of IL-17 in mammals. The IL-17 inhibitor is selected from specific anti-IL-17 antibody, siRNA or other any biochemical substances capable of reducing and / or knocking out expression of IL-17. The invention provides a medicament with new action mechanism for the treatment of influenza.

Description

technical field [0001] The present invention relates to the use of IL-17 in the preparation of medicines for treating and / or preventing Influenza A (H1N1) virus infection. Background technique [0002] IL17 (interleukin 17, interleukin 17, GeneID: 3605; Nucleotide: NM_002190.2; Protein: NP_002181.1) is an important cytokine, whether human or mouse T lymphocytes, microorganisms (such as spirochetes, mycobacteria, etc. ) can be induced to express IL-17. Microbe-induced long-term expression of IL-17 is an important mediator of infection-induced pathological immunity. Virus-mediated IL-17 gene transfer and high expression of IL-17 lead to increased expression of TNF-α, IL-1β, and G-CSF in the lungs, recruitment of polymorphonuclear cells, and increased bacterial clearance. [0003] IL-17, as an important mediator connecting T cells and neutrophils, stimulates bronchial epithelial cells, vascular endothelial cells and fibroblasts to synthesize and release biological factors suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/713A61K39/395A61K48/00A61P31/16
CPCA61K39/395A61K31/713A61K48/00C07K2317/76C07K16/244A61K45/00A61P31/16
Inventor 蒋澄宇王希良李承刚杨鹏辉孙阳邹镇
Owner THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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