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Preparation method for safflower care-free tablet

A safflower and xiaoyao technology, applied in the field of preparation of safflower xiaoyao tablets, can solve the problems of fast natural escape of volatile oil, low volatile oil retention index, long time for decoction, etc., and achieves short time and increased stability. , the effect of preventing volatilization

Active Publication Date: 2011-10-05
JIANGXI POZIN PHARMA
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The preparation method adopts the heat reflux method to extract the active ingredients in the medicinal material, which is easy to destroy the active ingredients that are unstable when exposed to heat due to decoction, the extraction rate is not high, the decoction takes a long time, and consumes energy; the volatile oil in the preparation method The most important addition is to spray the volatile oil directly on the granules, and then compress the tablet, so that the natural dissipation speed of the volatile oil is fast, and the retention index of the volatile oil with pharmacological effects in the preparation is not high

Method used

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  • Preparation method for safflower care-free tablet
  • Preparation method for safflower care-free tablet
  • Preparation method for safflower care-free tablet

Examples

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Effect test

Embodiment 1

[0037] Take 260g of Angelica sinensis, 260g of Atractylodes macrocephala and 40g of peppermint, crush them through a 40-mesh sieve, add 6.72Kg of water to soak for 2 hours, and extract the volatile oil by steam distillation for about 4 hours in water until the volatile oil in the oil-water separator no longer increases, and separates The volatile oil containing water was dried with anhydrous sodium sulfate to obtain 3.64ml of volatile oil, which was set aside. Take β-cyclodextrin 18.2g, make saturated aqueous solution, keep the temperature at 40 O C, add the above-mentioned volatile oil dropwise under stirring, stop stirring after 30min, let the reactant cool and move it into a refrigerator, in 3 O C was left for 24 hours to allow the inclusions to precipitate. After draining, remove the supernatant (save for next inclusion), suction and filter to dry the precipitate, 40 O C and dried in vacuum at low temperature to obtain 19.5 g of inclusion complexes of β-cyclodextrin in v...

Embodiment 2

[0041] Take 260g of Angelica sinensis, 260g of Atractylodes macrocephala and 40g of peppermint, crush them through a 40-mesh sieve, add 7.74Kg of water to soak for 2 hours, and extract the volatile oil by steam distillation for about 4 hours in water until the volatile oil in the oil-water separator no longer increases, and separates The volatile oil containing water was dried with anhydrous sodium sulfate to obtain 4.07ml of volatile oil, which was set aside. Take 20.4g of β-cyclodextrin to make a saturated aqueous solution, keep the temperature at 40°C, add the above-mentioned volatile oil dropwise under stirring, stop stirring after 30 min, let the reactant cool and move it into a refrigerator, and place it at 2-4°C The inclusions were allowed to settle for 24 hours. Afterwards, the supernatant was removed (reserved for the next inclusion), and the precipitate was obtained by suction filtration and vacuum drying at a low temperature of 40°C to obtain 23.8 g of inclusion com...

Embodiment 3

[0045] Take 520g of Angelica sinensis, 520g of Atractylodes macrocephala and 80g of peppermint, crush them through a 40-mesh sieve, add 13.44Kg of water to soak for 2 hours, and extract the volatile oil by steam distillation in water for about 4 hours until the volatile oil in the oil-water separator no longer increases, and separates The volatile oil containing water was dried with anhydrous sodium sulfate to obtain 7.28ml of volatile oil, which was set aside. Take 36.4g of β-cyclodextrin to make a saturated aqueous solution, keep the temperature at 40°C, add the above-mentioned volatile oil dropwise under stirring, stop stirring after 30 min, let the reactant cool and move it into a refrigerator, and place it at 2-4°C The inclusions were allowed to settle for 24 hours. Afterwards, the supernatant was removed (reserved for the next inclusion), and the precipitate was obtained by suction filtration, and vacuum-dried at a low temperature of 40°C to obtain 38.9 g of inclusion co...

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Abstract

The invention discloses a preparation method for a safflower care-free tablet, and relates to a preparation method for a traditional Chinese medicinal preparation. The method comprises the following steps: (1) extracting volatile oil of three traditional Chinese medicines, namely, Chinese angelica, bighead atractylodes rhizome and mint, by the method of steam distillation; (2) dissolving the herbresidue obtained in step (1) together with white peony root, Poria cocos, safflower, spina gleditsiae, herba bupleuri and licorice in water and obtaining water extract of the solution with supersonicwave; (3) including the volatile oil with beta-cyclodextrin so as to obtain volatile oil beta-cyclodextrin inclusion complex; (4) adding the water extract obtained in step (2) and the volatile oil beta-cyclodextrin inclusion complex obtained in step (3) into starch, carrying out granulation to form tablets and coating the tablets with thin film so as to obtain safflower care-free tablets. The invention enables effective ingredients in cells of the above-mentioned medicinal materials to dissolve rapidly and chemical constructions of the effective ingredients not to be destroyed, and therefore a high recovery rate is obtained. According to the invention, beta-cyclodextrin inclusion technique is employed to add the volatile oil, which effectively improves the retention index of volatile components of the above-mentioned medicinal materials in the preparation.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of Honghua Xiaoyao Tablet. Background technique [0002] Honghua Xiaoyao Tablet is the ninth new drug developed by Jiangxi Puzheng Pharmaceutical Co., Ltd. since 2005. Flavor medicine composition. Functions and indications are soothing the liver, regulating qi, and promoting blood circulation. It is used for discomfort of liver qi, chest pain, dizziness, loss of appetite, irregular menstruation, breast pain or chloasma on the face. [0003] The traditional preparation method of Honghua Xiaoyao Tablets is based on the prescription and production process of "Safflower Xiaoyao Capsules", and is obtained by simply changing the dosage form. The volatile oil is set aside; the dregs and the remaining six herbs are decocted twice with water, each time for 2 hours, filtered in several times, and the filtrates are combined and conc...

Claims

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Application Information

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IPC IPC(8): A61P7/00A61P1/16A61K9/48A61P29/00A61K47/40A61K36/71A61P15/00A61P17/00A61K9/30A61P25/00A61P1/14A61K9/16
Inventor 肖军平吴永忠李旭刘立鼎
Owner JIANGXI POZIN PHARMA
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