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Insecticidal synergistic composition

A composition and compound technology, applied in the directions of insecticides, biocides, animal repellents, etc., can solve the problems of short insecticidal control period, high cost, large dosage, etc. The effect of prolonging the control effect

Active Publication Date: 2013-05-29
德强生物股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Spiroindoline piperidine derivatives are a class of compounds capable of killing insects, acarids, nematodes and molluscs, but their single use costs are high, the dosage is large, and the period of insecticidal and control effects is short

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: the preparation of formula (I) compound

[0020] Step 1: Preparation of 5-chloro-3-methyl-2-sulfinylaminobenzoyl chloride

[0021]

[0022] Thionyl chloride (36ml, 500mmol) was added to a suspension of 2-amino-5-chloro-3-methyl-benzoic acid (18.5g, 100mmol) in toluene (200ml), the mixture was heated to reflux, and Stir at temperature until rapid gas evolution subsides. The resulting solution was concentrated under reduced pressure to give a solid residue, which was dried under high vacuum. The crude solid product (23.7 g, 95%) was used in the next step without further purification.

[0023] 1 H-NMR (CDCl 3 ): 8.07 (d, 1H), 7.56 (d, 1H), 2.30 (s, 3H).

[0024] Step 2: Preparation of 2-amino-2-cyclopropylpropionitrile

[0025]

[0026] Cool endomethyl ketone (17.1 g, 203 mmol) and 101.9 ml of 2.12 M NH with ice bath 4 Cl in H 2 Solution of stock solution (216 mmol) in O in 30.6 ml of 25% ammonium hydroxide (216 mmol). KCN (14.1 g, 216 mmol) wa...

Embodiment 2

[0036] Embodiment 2: the preparation of formula (II) compound

[0037] Step 1: Preparation of tert-butyl 4-methoxymethylenepiperidine-1-carboxylate

[0038] Potassium tert-butoxide (21.3 g) was added in portions to a stirred solution of methoxymethyltriphenylphosphonium chloride (65.3 g) in anhydrous THF (500 mL) at 4°C under a nitrogen atmosphere. A bright orange color was noted and the reaction was held as such for 1 hour. tert-Butyl 4-oxopiperidine-1-carboxylate 1 (25 g) was added slowly without allowing the temperature to rise above 10° C., then the mixture was heated at room temperature overnight.

[0039] The reaction mixture was poured into water (150 mL), extracted three times with ethyl acetate (100 mL), the combined organics were washed with brine (300 mL), dried over anhydrous sodium sulfate and concentrated in vacuo to give a brown oil (50 g) . Flash chromatography [SiO 2 ; hexane, then ethyl acetate-hexane (10:90)] afforded 26.4 g (77%) of the desired enol eth...

Embodiment 3

[0057] Separately apply formula (I) compound, formula (II) compound and use formula (I) compound and formula (II) compound composition separately on 1 mu of cornfield, formula (I) compound, formula (II) compound are formulated into The emulsifiable concentrate, formula (I) compound and formula (II) compound composition is formulated into emulsifiable concentrate preparation according to various proportioning, is used for preventing and controlling Spodoptera littoralis, counts the cotton on every acre of land respectively in 2 days, 5 days and 8 days The mortality rate of Spodoptera moth, the specific dosage and effect are as follows, where the percentage of control effect refers to the mortality rate of Spodoptera littoralis, and the higher the mortality rate, the better the control effect:

[0058] Experimental results

[0059]

[0060]

[0061] The expected activity of the given two active ingredient compositions is calculated according to the Colby method, and compared...

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Abstract

The invention relates to an insecticidal synergistic composition which comprises two active ingredients, namely, a compound of formula (I) and a compound of formula (II), wherein the compound of formula (I) and the compound of formula (II) exist at a proportion of synergistic effective dose; specifically, the weight ratio of the compound of formula (I) to the compound of formula (II) in the composition is 1:(0.01-100); when the two active ingredients of the pesticide are mixed for use, the insecticidal synergistic composition can reduce the applying amount of each pesticide while achieving the same control effect, and the two active ingredients of the pesticide show a synergistic effect when killing pests.

Description

technical field [0001] The invention belongs to the field of pesticide compositions, and in particular relates to an insecticidal pesticide composition and its application, in particular to an insecticidal synergistic composition containing anthranilamide derivatives and its application for controlling crop pests. Background technique [0002] Anthranilamide derivatives have a very favorable biocidal spectrum at low application rates and are well tolerated by warm-blooded species, fish and plants. Not only all or individual developmental stages of normally sensitive but also resistant animal pests, such as insects or typical organisms of the order Acarina, are acted upon. The insecticidal or acaricidal activity of the active ingredients of such compounds can be shown to be equivalent to at least 50% immediately or only after a period of time such as the death of the pest that occurs during molting, or indirectly, such as a reduction in egg laying and / or hatching Good activi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01N43/56A01P7/04
Inventor 杨强孙新宇王敏刘伟徐艳吉章丽
Owner 德强生物股份有限公司
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