Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Estimation method of biological sample completeness

A technology of biological samples and evaluation methods, which is applied in the field of evaluating the completeness of samples in the biological sample bank system, can solve the problems of expensive storage space, occupation, waste of precious samples and storage space, etc., and achieve the effect of improving utilization efficiency

Active Publication Date: 2013-09-04
ZHEJIANG UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method of sample transfer is likely to lead to two embarrassing situations: (1) biological samples that meet the requirements of high-level scientific research projects may be used for low-level projects, (2) biological samples that can only be used for low-level projects occupy expensive storage Space, resulting in a double waste of valuable samples and storage space

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Estimation method of biological sample completeness
  • Estimation method of biological sample completeness
  • Estimation method of biological sample completeness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A tumor biological sample bank system is selected. The storage subsystem of the sample bank saves the inventory of physical objects and the collection of data, and manages them in units of cases. Each case includes corresponding sample objects and sample materials. For the convenience of display, 11 samples in the library are selected for scoring, and the specific information of these samples taken from the storage subsystem is shown in Table 1.

[0045] Table 1

[0046]

[0047]

[0048] The information in Table 1 is explained as follows, serum: 0 = no serum sample, 1 = serum sample; mutation detection: 0 = no mutation detection data, 1 = mutation detection data; follow-up data: -1 = no follow-up, 0 = Unable to follow up, 1=1 follow-up record, 2=2 follow-up records, and so on; serial samples: 0=no serial samples, 2=2 serial samples, 3=3 serial samples , and so on;.

[0049] Step 1 lists the suspended cases nP={case k}, because case k is a case that has not been...

Embodiment 2

[0076] The example sample library in Example 1 is selected, but no field is disabled in Step 1, that is, nW={}, the subsequent calculation steps and formulas are the same as in Example 1, and the calculation results are shown in Table 5. It can be seen from Table 5 that the score of case g rises sharply without using the deactivated field. The reason is that case g contains the field “RH negative”, while other cases do not, which gives case g more scores. However, this field has basically nothing to do with the disease of tumor and will not be used for research. Therefore, it is necessary to deactivate such fields that have nothing to do with user needs to avoid affecting the score.

[0077] table 5

[0078] order

Embodiment 3

[0080] The sample sample library in Example 1 was selected, but in step 1 only the field "RH Negative" was disabled, that is, nW={RH Negative}, the subsequent calculation steps and formulas were the same as in Example 1, and the calculation results are shown in Table 5. It can be seen from Table 5 that the “name” and “sex” fields that are not disabled have no significant impact on the completeness ranking of cases, but the score gap between cases becomes smaller, and the ability to distinguish completeness of cases decreases when the sample size is large , it is also necessary to deactivate such mandatory data.

[0081] Table 6

[0082] order

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an estimation method of biological sample completeness, wherein sample material objects and sample data are reserved in a storage subsystem; the material object completeness and the data completeness of each case are computed in a grade subsystem so that a material stock and a data stock are respectively reflected; the material stock and the data stock are combined as a quantized estimation index of the biological sample entire completeness through a quadratic function relation; and finally a sample list ranked in order of completeness is provided for a user in a retrieval subsystem. In the invention, a low value case sample which meets the need of the user is preferentially used; a highly complete sample which exceeds the need of the user is reserved; consequently, the utilization ratio of biological samples and a sample database is improved. In the score field, the score of the field is obtained by computing the appearance times of the field in the case so that the scarity degree and the importance degree of the corresponding case are reflected naturally; and as new samples are put in storage and the data are updated, the score of the score index also is updated so that the method is objective, quantified, comprehensive and dynamically updatable.

Description

technical field [0001] The invention belongs to the technical field of biological sample preservation and utilization, and in particular relates to a method for evaluating sample integrity in a biological sample bank system. Background technique [0002] Biological samples are an essential foundation and source in the field of life science and pharmaceutical research and development, and are used for research such as diagnostic marker screening and therapeutic drug development. Biological samples contain rich genetic information, disease progress information, response information to treatment, etc., and are non-renewable. Standardized preservation and utilization of biological samples have become the most valuable resources in this field. An important guarantee for the research goal of "translational medicine". Under the premise of following medical ethics norms, biobanks of various scales have been established at home and abroad, especially biobanks for various major disea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G06F19/00G06F17/30
Inventor 葛维挺黄彦钦郑树周小宇
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com