Spraying agent for treating asthma and preparation method thereof

A technology for spray and asthma, applied in the field of traditional Chinese medicine preparations and their preparation, can solve the problems of difficulty in forming preparations, prone to adverse reactions, and difficult quality control, and achieves overcoming a variety of serious adverse reactions, mild systemic adverse reactions, and onset fast effect

Inactive Publication Date: 2012-01-04
GANSU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, at present, traditional Chinese medicines such as Angelica sinensis still mostly stay in the application of decoctions, and because most of them are compound preparations with more than ten herbs in practical applications, the preparations are difficult to form and difficult to control; It is very difficult for patients to take
On the other hand, oral preparations such as dripping pills based on Angelica volatile oil must be absorbed by the body into the blood circulation and reach the corresponding parts to play a therapeutic role, so that the amount of medicine arriving at the site of action is relatively small, and the onset of action is slow and the curative effect is poor; Drug concentrations in other parts are relatively high and adverse reactions are prone to occur

Method used

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  • Spraying agent for treating asthma and preparation method thereof
  • Spraying agent for treating asthma and preparation method thereof
  • Spraying agent for treating asthma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the preparation of spray

[0019] Accurately weigh 0.4g of Tween-80 and place it in a mortar, accurately weigh 0.2mL of volatile oil of Angelica sinensis and 0.05g of vitamin E, add it to the above mortar, grind and mix evenly, and then grind while adding distilled water at 35°C equal to the amount of volatile oil Until the colostrum is evenly mixed, transfer the above-mentioned colostrum to a high-speed tissue mash homogenizer; accurately weigh 0.1g of vitamin C and 0.02g of banana essence and add them to the high-speed tissue mash homogenizer; then add distilled water to the high-speed tissue mash homogenizer. In a tissue mash homogenizer, set the volume to 100mL, emulsify for 3 minutes at a stirring speed of 18,000 rpm, transfer it to a high-pressure homogenizer, and circulate and homogenize for 3 times under a pressure of 150MPa to obtain a white uniform milk liquid; encapsulate the prepared emulsion in a sprayer, 20mL per bottle, containing 0.04mL of ...

Embodiment 2

[0020] Embodiment 2: the preparation of spray

[0021] Accurately weigh 0.5g of Poloxamer-188 and put it in a mortar, accurately weigh 0.5mL of volatile oil of Angelica sinensis and 0.05g of vitamin E, add it to the above mortar, grind and mix evenly, then add distilled water at 35°C equal to the amount of volatile oil While grinding until the colostrum is evenly mixed, transfer the above-mentioned colostrum to a high-speed tissue mash homogenizer; accurately weigh 0.1g of vitamin C, and add 0.01g of banana essence, 0.01g of apple essence and 0.01g of corn essence to the high-speed Tissue mashing homogenizer; then add distilled water to the high-speed tissue mashing homogenizer, set the volume to 100mL, emulsify at 20000 rpm stirring speed for 5 minutes, then transfer it to the high-pressure homogenizer, Circulate and homogenize 3 times under 150MPa pressure to obtain a white uniform emulsion; encapsulate the prepared emulsion in a sprayer, 20mL per bottle, containing 0.1mL of...

Embodiment 3

[0022]Embodiment 3: the preparation of spray

[0023] Accurately weigh 0.5g of poloxamer-188 and 0.5g of Tween-80 and place them in a mortar, accurately weigh 1.0mL of volatile oil of Angelica sinensis and 0.05g of vitamin E into the above mortar, grind and mix evenly, and then add Grind the same amount of volatile oil with distilled water at 35°C until they are evenly mixed to obtain colostrum. g into the high-speed tissue homogenizer; then add distilled water to the high-speed tissue homogenizer, set the volume to 100mL, emulsify at a stirring speed of 25000 rpm for 6 minutes, then transfer it to a high-pressure homogenizer In the machine, circulate and homogenize for 3 times under a pressure of 150MPa to obtain a white uniform emulsion; encapsulate the prepared emulsion in a sprayer, 20mL per bottle, containing 0.2mL of volatile oil of Angelica sinensis, and store in a cool and dark place.

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Abstract

The invention discloses a spraying agent for treating asthma and a preparation method thereof. The spraying agent contains angelica volatile oil serving as an effective part for relieving asthma, and pharmaceutically allowable auxiliaries, wherein a spraying agent emulsion is prepared through weighing, mixing and setting volume, emulsifying and the like; and 0.2 to 15ml of the angelica volatile oil is contained in each 100ml of the spraying agent emulsion. The angelica volatile oil is easily volatized, has small local irritation, and is more suitable for administration in a local spraying inhalation, so that the medicament can directly reach a pathological position and has quick acting and good curative effect; and less drug is absorbed and enters blood circulation, and the adverse reaction of the whole body is light, so that the spraying agent is more suitable for long-term preventive administration in intermission phase of asthma. The volatile oil has the treatment effect on pulmonary hypertension, pulmonary heart disease, arrhythmia and other complications caused by chronic asthma while overcoming adverse reactions of beta2 receptor agonists and xanthine medicaments.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a spray mainly composed of Chinese angelica volatile oil for the prevention and treatment of bronchial asthma (abbreviated as asthma) and a preparation method thereof. Background technique [0002] The 2006 version of the Global Initiative for Asthma (The Global Initiative for Asthma, GINA) proposed that the global incidence of asthma is 1%-18%, and there are about 300 million asthma patients in the world; the prevalence of asthma in my country is about 2%, and children can According to estimates, there are more than 20 million asthma patients in the country. Asthma has become a major chronic disease that seriously threatens public health. [0003] At present, the chemicals used to treat asthma mainly include glucocorticoids, beta 2 Drugs such as receptor agonists and xanthines have definite and reliable curative effects, but they have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232A61K9/107A61K9/12A61P11/06
Inventor 任远王志旺吴国泰刘峰林
Owner GANSU UNIV OF CHINESE MEDICINE
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