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Chinese medicinal composition for preventing and treating hepatic fibrosis

A technology of liver fibrosis and composition, applied in the field of traditional Chinese medicine, can solve the problem of no approved anti-fibrotic drugs and the like

Inactive Publication Date: 2013-04-10
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, how to control liver fibrosis is still an international problem, and there is still no clinically approved anti-fibrosis drug

Method used

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  • Chinese medicinal composition for preventing and treating hepatic fibrosis
  • Chinese medicinal composition for preventing and treating hepatic fibrosis
  • Chinese medicinal composition for preventing and treating hepatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 900 grams each of Chinese herbal medicines Gentiana, Astragalus, Caulis Spatholobus, Safflower, and Angelica, and decoct them twice, starting from boiling for 1 hour each time. 10 times), the water quality for decocting for the second time is 36kg (8 times of the total medicinal material quality), and the two decoction liquids are combined and concentrated into 2000mL concentrate.

Embodiment 2

[0024] Take 1500 grams each of Chinese herbal medicines Gentiana, Astragalus, Millipede Spatholobus, Safflower, and Angelica, and decoct them in water for 2 times, each time starting from boiling for 1 hour. 10 times), the water quality for decocting for the second time is 60kg (8 times of the total medicinal material quality), the two decoction liquids are combined, and concentrated into 3000mL concentrate.

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Abstract

The invention discloses a Chinese medicinal composition for preventing and treating hepatic fibrosis. The Chinese medicinal composition is prepared from gentiana scabra bge, astragalus, suberect spatholobus stem, safflower and Chinese angelica which serve as Chinese medicinal materials in a mass ratio of 1:1:1:1:1. The Chinese medicinal composition is prepared by decocting the gentiana scabra bge, the astragalus, the suberect spatholobus stem, the safflower and the Chinese angelica which serve as the Chinese medicinal materials in water, extracting and concentrating. Pharmacodynamic tests prove that the Chinese medicinal composition can reduce the serum transaminase of hepatic fibrosis model rats and mice, relieve the deposit degree of liver collagen of the hepatic fibrosis model rats andmice and improve the liver inflammation and fibrotic pathological change of the hepatic fibrosis model rats and mice, has the effect of preventing and treating the pathological changes of hepatic fibrosis, and can be used for preparing medicament for preventing and treating hepatic fibrosis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for preventing and treating liver fibrosis, its preparation method and application, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Liver fibrosis is a common pathological process of many common chronic liver diseases (acute and chronic hepatitis, fatty liver, liver cancer, etc.), is the only way for chronic liver diseases to develop into cirrhosis, and is an important pathological factor affecting the prognosis of chronic liver diseases. All patients with chronic hepatitis B have varying degrees of liver fibrosis, and eventually progress to liver cirrhosis or liver cancer. For chronic hepatitis B, antiviral therapy alone cannot solve most of the progress of liver fibrosis in chronic hepatitis B, especially nearly 50% of patients with ineffective antiviral treatment are more l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/515A61P1/16
Inventor 崔红燕马越鸣顾伟梁刘平刘成海朱邦贤王峥涛陶艳艳
Owner SHANGHAI UNIV OF T C M
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