Traditional Chinese medicine composition for preventing and curing hepatic fibrosis, and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and curing hepatic fibrosis, and a preparation method and application thereof. The composition is prepared by taking traditional Chinese medicines, namely angelica, red flower, peach kernel, the root bark of the peony tree, root of common peony, Ligusticum wallichii, the root of three-nerved spicebush, trogopterus dung, corydalis tuber, rhizoma cyperi, fructus aurantii and liquorice, as raw materials according to the weight ratio of 9:9:9:6:6:6:6:9:3:5:5:9. The preparation method of the composition comprises the following steps of: taking the traditional Chinese medicines according to the ratio; decocting by using water for two times, each time for 1 h at the beginning of boiling, wherein the volume of water for the first time is 10 times as much as the total weight of the traditional Chinese medicines; and the volume of water for the second time is 8 times as much as the total weight of the traditional Chinese medicines; and finally, mixing the two kinds of decoction liquid and concentrating. The traditional Chinese medicine composition disclosed by the invention is capable of reducing serum transaminase, lightening liver collagen precipitation degree and improving hepatic inflammatory and fibrosis pathological change, has the function of preventing and curing hepatic fibrosis pathological change, and can be applied to preparing a pharmaceutical preparation for preventing and curing hepatic fibrosis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for preventing and treating liver fibrosis, a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. Background technique [0002] Liver fibrosis refers to the excessive proliferation and abnormal deposition of diffuse extracellular matrix in the liver. Liver fibrosis is not an independent disease, but a common pathological process of many chronic liver diseases. Almost all kinds of chronic liver diseases, including chronic hepatitis B (C) virus, chronic schistosomiasis, chronic alcohol and drug damage, and autoimmune liver disease all have this chronic pathological change. The continuous development of liver fibrosis can further lead to liver cirrhosis and even liver cancer, seriously affecting the health and life of patients. Therefore, slowing down, preventing and reversing liver fibrosis is an important therapeutic strateg...

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Problems solved by technology

However, there is still no clinically approved anti-fibrosis western medicine

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