Medicine for preventing and treating peritoneal fibrosis and application method

Abstract

The invention belongs to the technical field of organic chemistry, and discloses a medicine for preventing and treating peritoneal fibrosis and an application method. The medicine for preventing and treating peritoneal fibrosis is matrine. Matrine can relieve a plurality of organ fibrosis. In the process of liver fibrosis in chronic hepatitis B patients, matrine can significantly reduce serum liver fibrosis-related indexes, and promote the improvement of CCL4-induced liver fibrosis model rat related liver indexes. The alkaloids of radix sophorae flavescentis include 23 alkaloids such as matrine, sophoridine, isomatrine, sophocarpine. Alkaloids are active ingredients of matrine and have the effects of being antiviral, anti-inflammatory, anti-tumor and the like. The use of matrine inhibits / destroys the formation of bacterial mycoderm, thereby inhibiting the occurrence of peritoneal fibrosis and reducing the use of antimicrobial agents and the occurrence of drug resistance.

Description

technical field [0001] The invention belongs to the technical field of organic chemistry, in particular to a medicine for preventing and treating peritoneal fibrosis and its application method. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: Peritoneal dialysis is one of the important alternative therapies for patients with end-stage renal failure. At present, the number of peritoneal dialysis patients in the world is about 115,000, accounting for 14% of the total number of dialysis patients, and the number is growing rapidly. The successful progress of peritoneal dialysis mainly depends on the normal structure and function of the peritoneum. Peritoneal dialysis-associated peritonitis and ultrafiltration failure are the most serious complications of peritoneal dialysis, which are important reasons for the failure of peritoneal dialysis in patients with peritoneal dialysis. Recurrent peritonitis will acceler...

AI Technical Summary

Problems solved by technology

Recurrent peritonitis will accelerate the loss of peritoneal function, peritoneal fibrosis, and decline in dialysis efficiency, further promoting peritoneal dialysis ultrafiltration failure

Even if peritonitis is completely relieved by effective antibiotic treatment, a large number of experiments have proved that due to the activation of the TFG-β1 / R-Smad signaling pathway, a large number of inflammatory mediators and pro-sclerosing factors are still released, which continuously damages peritoneal mesothelial cells and causes a large amount of collagen The production and deposition of peritoneal fibrosis is one of the important problems restricting the clinical application of peritoneal dialysis

At present, there is no effective clinical method for the prevention and treatment of peritonitis-related peritoneal fibrosis, so it is necessary to find safe and effective drugs for the treatment of peritonitis-related peritoneal fibrosis

[0003] In summary, the problems in the prior art are: Existing peritoneal dialysis methods produce a large amount of inflammatory mediators and pro-sclerosing factors, which continuously damage peritoneal mesothelial cells and lead to peritoneal fibrosis

[0004] The difficulty and significance of solving the above technical problems: At present, the main treatment for peritonitis caused by bacterial infection is to use antibiotics. The bacteria in peritoneal infection are mainly staphylococcus and other bacteria, and there are also fungi. Different bacteria and fungi have different toxicity and virulence, and the mechanism of action on the peritoneum is also different. , and once the corresponding pathway is activated, various inflammatory mediators and pro-sclerosing factors are released in a cascade, even if the pathogenic bacteria are completely eliminated, the cascade release of inflammatory mediators and pro-sclerosing factors cannot be reversed

In addition, the use of antibacterial drugs for long-term and repeated infections leads to drug resistance, thereby promoting the production of superbugs is the main problem at present

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