The Application of Tetrahydrocurcumin in Improving Allergic Asthma
A tetrahydrocurcumin, allergy technology, applied in the field of biomedicine, to achieve good application prospects, inhibit the production of Th2 cytokines, and reduce the effect of lung collagen deposition
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Embodiment 1 4
[0022] Embodiment 1 Tetrahydrocurcumin alleviates the allergic symptoms of scratching the nose in asthmatic mice
[0023] Establishment of allergic asthma mouse model and tetrahydrocurcumin intervention method:
[0024] On days 0, 7, and 14, the mice in the model group were injected with 200 μL ovalbumin (OVA) sensitization solution (containing 40 μg OVA+4 mg aluminum hydroxide, constant volume in PBS) in the left lower abdominal cavity. At intervals of 1 week, starting from the 21st day, a 5% OVA solution was prepared for nebulized inhalation. Specifically: Number the mice, put them into a transparent plastic container with a small hole about 2.5 cm in diameter on the side, and put the nozzle of the compressed air atomizer into it. Then the nebulizer was turned on, and the mice were inhaled by nebulization for 30 minutes. After 30 minutes, 40 μg / μL of OVA solution was instilled into the nasal cavity of the mouse, 10 μL in each nasal cavity, that is, 400 μg of OVA was instil...
Embodiment 2 4
[0027] Embodiment 2 Tetrahydrocurcumin improves lung pathological changes in asthmatic mice
[0028] Methods: Mouse lung tissues were fixed in 10% formalin for 24-48 hours, embedded in paraffin and cut into 4μm thick sections. HE staining, periodic acid-Schiff (PAS) staining and Masson staining were performed on the sections, and eosinophil infiltration, mucus secretion and collagen deposition were observed respectively.
[0029] Results: The pathological changes in the lungs of asthmatic mice were observed and evaluated by HE staining, PAS staining, and Masson staining, see figure 2 . It was found from the figure that asthmatic mice group (OVA) had obvious eosinophil infiltration, increased goblet cell mucus production, and increased collagen deposition (P Figure 3-5 ).
Embodiment 3 4
[0030] Example 3 Tetrahydrocurcumin inhibits Th2 cells and Th2 cytokines in lung tissue of asthmatic mice
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