The Application of Tetrahydrocurcumin in Improving Allergic Asthma

A tetrahydrocurcumin, allergy technology, applied in the field of biomedicine, to achieve good application prospects, inhibit the production of Th2 cytokines, and reduce the effect of lung collagen deposition

Active Publication Date: 2020-09-08
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, no research has been reported on the effects of THC on asthma

Method used

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  • The Application of Tetrahydrocurcumin in Improving Allergic Asthma
  • The Application of Tetrahydrocurcumin in Improving Allergic Asthma
  • The Application of Tetrahydrocurcumin in Improving Allergic Asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 4

[0022] Embodiment 1 Tetrahydrocurcumin alleviates the allergic symptoms of scratching the nose in asthmatic mice

[0023] Establishment of allergic asthma mouse model and tetrahydrocurcumin intervention method:

[0024] On days 0, 7, and 14, the mice in the model group were injected with 200 μL ovalbumin (OVA) sensitization solution (containing 40 μg OVA+4 mg aluminum hydroxide, constant volume in PBS) in the left lower abdominal cavity. At intervals of 1 week, starting from the 21st day, a 5% OVA solution was prepared for nebulized inhalation. Specifically: Number the mice, put them into a transparent plastic container with a small hole about 2.5 cm in diameter on the side, and put the nozzle of the compressed air atomizer into it. Then the nebulizer was turned on, and the mice were inhaled by nebulization for 30 minutes. After 30 minutes, 40 μg / μL of OVA solution was instilled into the nasal cavity of the mouse, 10 μL in each nasal cavity, that is, 400 μg of OVA was instil...

Embodiment 2 4

[0027] Embodiment 2 Tetrahydrocurcumin improves lung pathological changes in asthmatic mice

[0028] Methods: Mouse lung tissues were fixed in 10% formalin for 24-48 hours, embedded in paraffin and cut into 4μm thick sections. HE staining, periodic acid-Schiff (PAS) staining and Masson staining were performed on the sections, and eosinophil infiltration, mucus secretion and collagen deposition were observed respectively.

[0029] Results: The pathological changes in the lungs of asthmatic mice were observed and evaluated by HE staining, PAS staining, and Masson staining, see figure 2 . It was found from the figure that asthmatic mice group (OVA) had obvious eosinophil infiltration, increased goblet cell mucus production, and increased collagen deposition (P Figure 3-5 ).

Embodiment 3 4

[0030] Example 3 Tetrahydrocurcumin inhibits Th2 cells and Th2 cytokines in lung tissue of asthmatic mice

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Abstract

The invention discloses application of tetrahydrocurcumin in treating allergic asthma. The therapeutic action of the tetrahydrocurcumin (THC) on allergic asthma is firstly found and proved; from the perspective of immunity, the THC can be beneficial to alleviating nose allergy and itching, inhibiting lung eosinophilic granulocyte infiltration, reducing lung goblet cell grume generation, reducing lung collagen deposition, and inhibiting Th2 cell factor production, can provide beneficial information for clinic disease evaluation, and has a favorable application prospect in asthma treatment.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to the application of tetrahydrocurcumin in treating allergic asthma. Background technique [0002] Allergic asthma is a chronic airway inflammatory disease characterized by increased inflammatory cell infiltration (especially eosinophils), abnormal airway remodeling (goblet cell metaplasia and smooth muscle cell hyperplasia), and increased levels of various inflammatory cytokines. High (type 2 helper T cell (Th2) predominant response) is characterized. In allergic asthma, the dominance of Th2 cells is related to the onset and progression of the disease, and the interleukin (interleukin) IL-4, IL-5 and IL-13 produced by Th2 cells promote the occurrence and development of allergic asthma. [0003] Curcumin (Cur) is a natural pigment present in the rhizome of Curcuma longa, which has a series of physiological activities, including anti-inflammatory, anti-cancer, and anti-oxidation effects....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61P11/06A61P37/08A61P17/04
CPCA61K31/12A61P11/06A61P17/04A61P37/08
Inventor 杨燕陈彦球李春炜陈彬林曾清香
Owner SUN YAT SEN UNIV
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