Preparation method of levofloxacin lactate and sodium chloride injection

A technology of levofloxacin lactate and sodium chloride injection, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, drug delivery and other directions, can solve the problems of poor stability and solubility of levofloxacin lactate and sodium chloride injection.

Inactive Publication Date: 2012-01-18
ANHUI GLOBAL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor stability and solubility of levofloxacin lactate s

Method used

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  • Preparation method of levofloxacin lactate and sodium chloride injection

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Experimental program
Comparison scheme
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Embodiment

[0018]

[0019] Preparation:

[0020] 1. Add about 1 / 2 amount of water for injection into the clean concentrated compounding tank, and slowly pour 9kg of sodium chloride for injection into the concentrated compounding tank to dissolve it while the concentrated compounding tank is turned on and stirred. To prevent sinking and agglomeration, the medicinal powder adhered to the tank wall should be rinsed with water for injection, and after it is completely dissolved, add medicinal charcoal 0.05% (W / V is calculated by dilute volume), stir evenly, and steam into the interlayer to heat and boil , and keep boiling for 5 minutes, turn off the steam.

[0021] 2. After the concentrated material is filtered to remove charcoal, add the dilute compounding tank, add water for injection at the same time and turn on the dilute compounding tank to stir. inside the tank.

[0022] 3. Add an appropriate amount of water for injection into a clean plastic container, slowly add the weighed levo...

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Abstract

The invention relates to a preparation method of a levofloxacin lactate and sodium chloride injection, and the method comprises the steps such as dense preparing, heating, filtering, diluted preparing, pH value regulating, filtering, filling, sealing, sterilizing, inspecting and the like. The levofloxacin lactate and sodium chloride injection prepared by the preparation method has good stability, and can completely be packaged by adopting a plastic bottle.

Description

technical field [0001] The invention relates to a preparation method of levofloxacin lactate sodium chloride injection, in particular to a preparation method of levofloxacin lactate sodium chloride injection with good stability. Background technique [0002] Levofloxacin lactate is a third-generation quinolone broad-spectrum antibacterial drug. Its injection is clinically used to treat infections caused by sensitive bacteria, and its curative effect is definite. Due to the poor stability and solubility of levofloxacin lactate sodium chloride injection, it is currently packaged in glass bottles. However, infusion products packaged in plastic bottles have the characteristics of light weight, convenient transportation, unbreakable bottle body, easy to ensure product quality, and easy-to-open bottle caps with easy-pull ring design, etc., which have been widely used in medical institutions at all levels in my country in recent years. It is popular among medical workers; in additi...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/5383A61K47/02A61P31/04
Inventor 魏科
Owner ANHUI GLOBAL PHARM CO LTD
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