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Traditional Chinese medicine pill for treating uterine fibroids and preparation method thereof

A technology for uterine fibroids and dropping pills, applied in the directions of pill delivery, anti-tumor drugs, pharmaceutical formulations, etc., can solve problems such as affecting hormone secretion levels, disrupting physiological balance, prolonging recovery period, etc., to improve extraction efficiency and simplify formulations. , the effect of reducing the operation steps

Active Publication Date: 2013-06-12
陕西步长高新制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical treatment of uterine fibroids generally adopts mifepristone, androgen, tripterygium glycosides and other drugs and surgical treatment. Although the uterine fibroids shrink after the above drug treatment, the side effects are large, which usually affect the normal internal organs of the human body. The level of hormone secretion destroys the normal physiological balance of the human body, and different degrees of masculine characteristics appear. After stopping the drug, the fibroids grow again, and it is difficult to completely cure them
The effect of surgical treatment is good, but surgical treatment brings greater trauma to the patient, prolongs the recovery period, and the patient's ability to accept it is poor

Method used

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  • Traditional Chinese medicine pill for treating uterine fibroids and preparation method thereof
  • Traditional Chinese medicine pill for treating uterine fibroids and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] (1) Take 64g of Sanleng, 64g of Curcuma Radix, and 64g of Atractylodes Rhizoma, add 10 times the weight of the medicinal materials and soak in water, and after ultrasonic treatment at 80kHz for 30min, extract the volatile oil twice by steam distillation, 1h each time, after collecting the volatile oil, Inclusion with β-cyclodextrin whose weight ratio to the volatile oil is 3 times the amount, the distilled aqueous solution is filtered for subsequent use, and the medicinal residues are added with 128 g of Cyperus chinensis and 128 g of Cortex Moutan, and the ethanol with a weight ratio of 8 times the amount of the medicinal materials is added, Extraction by heating and refluxing for 2 times, 1 h each time, filtration, combined filtrates under reduced pressure to recover ethanol, and concentrated under reduced pressure at 60°C into a clear paste with a relative density of 1.20 for use;

[0096] (2) Take soil soft-shelled turtle 64g, Codonopsis 64g, Evodia 64g, Hedyotis dif...

Embodiment 2

[0099] (1) Take 64g of Sanleng, 64g of Curcuma radix, and 64g of Atractylodes Rhizoma, add 8 times the weight of the medicinal materials and soak in water, and after ultrasonic treatment at 100kHz for 15min, extract the volatile oil by steam distillation for 3 times, 1.5h each time, after collecting the volatile oil , with the β-cyclodextrin that the weight ratio of the volatile oil is 2 times the amount, the distilled aqueous solution is filtered for later use, the medicinal residues are added 128g of Cyperus chinensis, 128g of Cortex Moutan, and the ethanol that is 6 times the weight ratio of the medicinal material is added. , heated and refluxed for extraction once, 2h each time, filtered, combined the filtrate under reduced pressure to recover ethanol, and concentrated under reduced pressure at 60°C into a clear paste with a relative density of 1.10 for later use;

[0100] (2) Take soil soft-shelled turtle 64g, Codonopsis 64g, Evodia 64g, Hedyotis diffusa 210g, Agrimony 126...

Embodiment 3

[0103](1) Take 64g of Sanleng, 64g of Curcuma Radix, and 64g of Atractylodes Rhizoma, add 12 times the weight of the medicinal materials and soak in water, and after ultrasonic treatment at 40Hz for 45min, extract the volatile oil by steam distillation for 3 times, 2h each time, after collecting the volatile oil, Inclusion with β-cyclodextrin whose weight ratio to the volatile oil is 4 times of the amount, the distilled aqueous solution is filtered for subsequent use, the medicinal residues are added to 128 g of Cyperus officinalis and 128 g of Cortex Moutan, and the ethanol of 10 times the weight ratio of the medicinal material is added, Heating and refluxing extraction for 3 times, 1.5h each time, filtration, combined filtrates under reduced pressure to recover ethanol, and concentrated under reduced pressure at 60°C to form a clear paste with a relative density of 1.30 for later use;

[0104] (2) Take soil soft-shelled turtle 64g, Codonopsis 64g, Evodia 64g, Hedyotis diffusa...

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Abstract

The invention relates to a traditional Chinese medicine pill for treating uterine fibroids and a preparation method thereof. The traditional Chinese medicine pill is prepared by taking 210 parts of oyster, 128 parts of prepared rhizoma cyperi, 64 parts of rhizoma sparganii, 64 parts of zedoary, 64 parts of ground beetle, 64 parts of dangshen, 64 parts of largehead atractylodes rhizome, 64 parts of fructus evodiae, 210 parts of spreading hedyotis herb, 126 parts of herba agrimoniae and 128 parts of cortex moutan as raw materials and adding pharmaceutically acceptable auxiliary materials after extracting and purifying the raw materials according to certain processes. The traditional Chinese medicine pill has the characteristics of simple and feasible preparation process, safety, effectiveness and obvious pharmacological and pharmacodynamic effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine dropping pill for treating uterine fibroids and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Uterine fibroids, also known as uterine fibroids, are the most common benign tumors in the female reproductive system. The incidence of reproductive women is about 25%, and it accounts for about 51.87% of all benign tumors in women. The pain, inflammatory swelling, etc. caused by it is a common complication. The most common clinical symptoms are: uterine bleeding, lower abdominal pain and dysmenorrhea, oppressive symptoms, increased vaginal secretions, anemia, and even infertility, which seriously affect women's health and daily work. May turn into malignant tumors. [0003] At present, the etiology and pathogenesis of uterine fibroids are complex. Classical studies believe that uterine fibroids are benign ovarian tumors that...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/9066A61P15/00A61P35/00A61K35/64A61K35/56A61K35/618
Inventor 赵涛
Owner 陕西步长高新制药有限公司
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