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Chinese medicinal soft capsule for treating uterine fibroid and preparation method thereof

A technology of soft capsules and uterine fibroids, applied in the field of pharmaceutical preparations, can solve problems such as disrupting physiological balance, affecting hormone secretion levels, prolonging the recovery period, etc., and achieve the effects of reducing operation steps, improving extraction efficiency, and ensuring stability

Active Publication Date: 2013-04-10
陕西步长高新制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical treatment of uterine fibroids generally adopts mifepristone, androgen, tripterygium glycosides and other drugs and surgical treatment. Although the uterine fibroids shrink after the above drug treatment, the side effects are large, which usually affect the normal internal organs of the human body. The level of hormone secretion destroys the normal physiological balance of the human body, and different degrees of masculine characteristics appear. After stopping the drug, the fibroids grow again, and it is difficult to completely cure them
The effect of surgical treatment is good, but surgical treatment brings greater trauma to the patient, prolongs the recovery period, and the patient's ability to accept it is poor

Method used

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  • Chinese medicinal soft capsule for treating uterine fibroid and preparation method thereof
  • Chinese medicinal soft capsule for treating uterine fibroid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] (1) Take 64g of Sanleng, 64g of Curcuma Rhizoma, and 64g of Atractylodes Rhizoma Atractylodes Rhizome, soak them in water with a weight ratio of 10 times that of the medicinal materials, and use 80kHz ultrasonic treatment for 30 minutes, then extract the volatile oil twice by steam distillation, 1 hour each time, after collecting the volatile oil, Use β-cyclodextrin in an amount 3 times the weight ratio of the volatile oil, and filter the distilled aqueous solution for later use. Add 128 g of Rhizoma Cyperi and 128 g of Cortex Moutan, and add ethanol in an amount 8 times the weight ratio of the medicinal material. Heat and reflux extraction twice, each time for 1 hour, filter, combine the filtrate to recover ethanol under reduced pressure, and concentrate under reduced pressure at 60°C to form a clear paste with a relative density of 1.20 for later use;

[0099] (2) Take 64g of ground beetle, 64g of Codonopsis pilosula, 64g of Evodia rutaecarpa, 210g of Hedyotis diffusa,...

Embodiment 2

[0103] (1) Take 64g of Sanleng, 64g of Curcuma, and 64g of Atractylodes Rhizome, soak them in water with a weight ratio of 8 times that of the medicinal materials, and use 40kHz ultrasonic treatment for 45min, then extract the volatile oil by steam distillation for 3 times, each time for 1.5h, after collecting the volatile oil , with the β-cyclodextrin clathrate of 4 times the weight ratio of the volatile oil, the distilled aqueous solution is filtered and set aside, the medicinal dregs are added with 128g of Rhizoma Cyperi, 128g of Cortex Moutan, and ethanol with a weight ratio of 10 times of the medicinal material is added , heated and refluxed once for 1.5 hours each time, filtered, combined the filtrate to recover ethanol under reduced pressure, and concentrated under reduced pressure at 60°C to form a clear paste with a relative density of 1.30 for later use;

[0104] (2) Take 64g of ground beetle, 64g of Codonopsis pilosula, 64g of Evodia rutaecarpa, 210g of Hedyotis diff...

Embodiment 3

[0108] (1) Take 64g of Sanleng, 64g of Curcuma Rhizoma, and 64g of Atractylodes Rhizoma Atractylodes Rhizome, soak in water with a weight ratio of 12 times that of the medicinal materials, and use 100kHz ultrasonic treatment for 15 minutes, then extract the volatile oil by steam distillation for 3 times, each time for 2 hours, after collecting the volatile oil, Use β-cyclodextrin with a weight ratio of 2 times that of the volatile oil to clathrate, and filter the distilled aqueous solution for later use. Add 128 g of Rhizoma Cyperi and 128 g of Cortex Moutan, and add ethanol with a weight ratio of 6 times that of the medicinal materials. Heat and reflux extraction 3 times, each time for 2 hours, filter, combine the filtrate to recover ethanol under reduced pressure, and concentrate under reduced pressure at 60°C to form a clear paste with a relative density of 1.10 for later use;

[0109] (2) Take 64g of soil beetle, 64g of Codonopsis pilosula, 64g of Evodia rutaecarpa, 210g of...

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Abstract

The invention relates to a Chinese medicinal soft capsule for treating uterine fibroid and a preparation method thereof. The soft capsule is prepared by extracting and purifying the following raw materials in parts by weight: 210 parts of oyster, 128 parts of prepared nutgrass galingale rhizome, 64 parts of rhizoma sparganii, 64 parts of curcuma zedoary, 64 parts of ground beetle, 64 parts of pilose asiabell root, 64 parts of bighead atractylodes rhizome, 64 parts of evodia rutaecarpa, 210 parts of spreading hedyotis herb, 126 parts of hairyvein agrimony and 128 parts of tree peony bark together with pharmaceutically acceptable auxiliary materials according to a certain process. The Chinese medicinal preparation provided by the invention has the characteristics of simple and practical preparation process, safety and effectiveness and remarkable pharmacological efficacy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine soft capsule for treating uterine fibroids and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Uterine fibroids, also known as uterine fibroids, are the most common benign tumors of the female reproductive system. The incidence rate of women in the childbearing period is about 25%, accounting for about 51.87% of all benign tumors in women. Pain, inflammatory swelling, etc. caused by it is its common complication. Its most common clinical symptoms are: uterine bleeding, lower abdominal pain and dysmenorrhea, compression symptoms, increased vaginal secretions, anemia, and even infertility, which seriously affects women's health and daily work. May transform into a malignant tumor. [0003] At present, the etiology and pathogenesis of uterine fibroids are complicated. Classical studies believe that uterine fibroids are ben...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/48A61P15/00A61P35/00A61K35/64A61K35/56A61K35/618
Inventor 赵涛
Owner 陕西步长高新制药有限公司
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