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Device for detecting bladder cancer

A technology for bladder cancer and detection reagents, which is applied to devices for judging whether a subject suffers from bladder cancer, and to detect Polo-like kinase 2 in the urine of subjects, which can solve the problems of low sensitivity and accuracy, high detection costs, and the impact of Screening results and other issues to achieve accurate screening results

Inactive Publication Date: 2012-02-01
陈黎明 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the sensitivity and accuracy of urine cytology examination based on cell morphology interpretation are low, and it is often impossible to distinguish cells with low mutations, thus affecting the screening results
As for cystoscopy and pathological tissue section examination, although the sensitivity and accuracy are high, the detection cost is expensive and it will cause the suffering of the examinee.

Method used

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  • Device for detecting bladder cancer
  • Device for detecting bladder cancer
  • Device for detecting bladder cancer

Examples

Experimental program
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preparation example

[0046] The sample receiving pad, detection reagent pad, display film, and absorbent pad in the device of the present invention are prepared according to the following steps.

[0047] Preparation of sample receiving pads and absorbent pads

[0048] The sample receiving pad and absorbent pad used a non-woven, 100% pure cellulose fiber pad (C048, Millipore, MA, USA). The sample receiving pad was cut to a size of 15×300 mm, and soaked in a solution containing 20 mmol / L sodium borate, 2.0 wt / vol% sucrose, 2.0 wt / vol% bovine serum albumin, and 0.1 wt / vol % sodium azide buffer (pH 8.0), and then dried at 56°C for 1 hour. Absorbent pads are cut to a size of 40 x 300 mm. Store the sample receiving pad and absorbent pad at room temperature with a desiccant.

[0049] Preparation of Assay Reagent Pads

[0050] Use a solution containing 8.75 wt / vol% sucrose, 8.75 wt / vol% bovine serum albumin, 0.6 mol / liter sodium chloride, 10 mmol / liter ethylenediaminetetraacetic acid (EDTA), and 0.1 w...

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Abstract

The invention relates to a device for detecting bladder cancer. The device comprises a sample receiving pad, a detecting reagent pad, a display film and an absorbing pad, wherein the sample receiving pad is used for absorbing a urine sample; the detecting reagent pad is connected to the sample receiving pad and comprises a first antibody of Polo-like kinase 2 and a metal grain combined with the first antibody; the display film is connected to the detecting reagent pad and comprises a detecting area and a quality control area; the absorbing pad is connected to the quality control area of the display film; the detecting area is located between the quality control area and the detecting reagent pad and comprises a protein fixed on the detecting area and a Polo-like kinase 2 combined with the protein; and the quality control area comprises a second antibody fixed thereon and the second antibody is the antibody of the first antibody. The device can be used for conveniently, quickly and accurately detecting bladder cancer.

Description

technical field [0001] The present invention relates to a device for detecting bladder cancer, in particular to a device for detecting Polo-like kinase 2 (Polo-like kinase 2, PLK2) in the urine of a subject to determine whether the subject suffers from bladder cancer installation. Background technique [0002] Bladder cancer is the most common malignant tumor that occurs in the urinary system. About 100,000 people worldwide suffer from bladder cancer every year, three-quarters of whom are men, and most of them are middle-aged and elderly people. It is generally believed that the occurrence of bladder cancer is related to factors such as diet, smoking or chemical carcinogens (such as arsenic). [0003] Bladder cancer has no obvious symptoms in the early stage. Once symptoms such as painless hematuria, frequent urination, dysuria, lower abdominal pain, and dysuria appear, it is usually in the middle and late stages of bladder cancer. Bladder cancer tumors develop rapidly and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/558
Inventor 陈黎明高忠汉
Owner 陈黎明
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