Carboxymethyl chitosan nanoparticles modified with glycyrrhizic acid, preparation method and application thereof
A technology of carboxymethyl chitosan and nanoparticles, which is applied in the field of liver tumor-targeted glycyrrhizic acid modified carboxymethyl chitosan nanoparticles and its preparation, can solve the problem of liver cancer cells that have not been shown to have active targeting and have not yet been identified. Effectively exert the active targeting effect of glycyrrhizic acid and other issues to achieve the effect of improving cell uptake efficiency, realizing long circulation in the body, and avoiding clearance
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Embodiment 1
[0053] The preparation of embodiment 1 carboxymethyl chitosan nanoparticles
[0054] Take 1 g of carboxymethyl chitosan with a molecular weight of 10,000 Da, add it to 100 mL of water, and stir at room temperature until completely dissolved. Heat to 40°C, add 0.5 mL methyl methacrylate, stir for 20 min, add 0.05 g ammonium persulfate, slowly raise the temperature to 70°C, and continue the reaction for 24 h. The milky white nanoparticle suspension obtained from the reaction was dialyzed and purified in a 14,000 Da semipermeable membrane, and freeze-dried.
Embodiment 2
[0055] The preparation of embodiment 2 carboxymethyl chitosan nanoparticles
[0056] Take 1 g of carboxymethyl chitosan with a molecular weight of 10,000 Da, add it to 100 mL of water, and stir at room temperature until completely dissolved. Heat to 30°C, add 0.25 mL of methyl methacrylate, stir for 10 min, add 0.01 g of ammonium persulfate, slowly raise the temperature to 75°C, and continue the reaction for 12 h. The milky white nanoparticle suspension obtained from the reaction was dialyzed and purified in a 14,000 Da semipermeable membrane, and freeze-dried.
Embodiment 3
[0057] The preparation of embodiment 3 carboxymethyl chitosan nanoparticles
[0058] Take 1 g of carboxymethyl chitosan with a molecular weight of 10,000 Da, add it to 100 mL of water, and stir at room temperature until completely dissolved. Heat to 50°C, add 4 mL of methyl methacrylate, stir for 30 min, add 0.2 g of ammonium persulfate, slowly raise the temperature to 85°C, and continue the reaction for 2 h. The milky white nanoparticle suspension obtained from the reaction was dialyzed and purified in a 14,000 Da semipermeable membrane, and freeze-dried.
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