Magnetic nanometer particulate of liposoluble photosensitizer and method for preparing the same

Abstract

The present invention relates to a magnetic nanoparticle of a fat-soluble photosensitizer and a preparation method thereof; the present invention is the composite nanoparticle with the size of 5nm to 300nm which consists of 30 percent to 70 percent polysaccharide polymer, 5 percent to 40 percent fat-soluble photosensitizer and 10 percent to 50 percent iron-containing magnetic particles which havethe magnetic response under the function of external magnetic field. The preparation method thereof is that the polysaccharide polymer is dissolved in alkaline solution, the emulsifier is added, the organic solvents which dissolves the fat-soluble photosensitizer are dropped during the agitating, so as to form the emulsion; the hydrate of ferrous salts and ferric salts is dropped into the emulsion during the agitating, so as to generate the black precipitate, then the magnetic nanoparticle of the fat-soluble photosensitizer can be obtained through the heating, pH valve regulation, getting thesolid phase, washing, freezing and drying sequentially. The present invention has the advantages of safety, no toxicity, strong magnetic response and good biological acceptability, can entirely achieve the intravenous administration and significantly improve the targeting of the tumor under the magnetic guide function, so as to improve the photosensitive activity of the photosensitizer and achieve the purposes of reducing the dosage and lowering the toxic and side effects.

Description

(1) Technical field [0001] The invention relates to a method for preparing magnetic nanoparticle in medical treatment, in particular to a method for preparing magnetic nanoparticle of fat-soluble photosensitizer used in photodynamic therapy of tumors. (two), background technology [0002] Malignant tumors seriously threaten human health. According to the forecast of the World Health Organization (WHO), by 2020, the number of new malignant tumor patients will reach 15 million each year. Among the many methods of tumor treatment, photodynamic therapy (Photodynamic Therapy, PDT) stands out for its advantages of effectiveness, safety, small side effects, synergy, reproducibility and relatively low cost, and has shown great promise in the treatment of tumors. Strong vitality. At present, photodynamic therapy has been officially used in the clinical treatment of various tumors in the United States, Britain, Germany, Japan and other countries. [0003] An important factor determ...

AI Technical Summary

Problems solved by technology

The particle size obtained by this method is too large (10-1000nm), and for particles in the range of (300nm-1000nm), it is extremely easy to be captured by macrophages, thereby affecting the bioavailability of the drug

The biggest deficiency of this magnetic nano particle is: in the preparation process, it directly uses ferric oxide as raw material, it is very difficult to make ferric oxide directly wrapped in chitosan, in order to solve this problem, it Choose to add the cross-linking agent glutaraldehyde for cross-linking polymerization, and glutaraldehyde is very easy to react with the active ingredients in the drug, which seriously affects the efficacy and safety of the active ingredients in the drug

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