Composite nano-microsphere with fast mucus penetration and its preparation method and application

A technology of nano-microspheres and polymers, applied in the field of biomedical materials, can solve the problems of difficult and effective penetration of nanoparticles, reduce the effect of drug treatment, etc. Effect

Active Publication Date: 2021-06-25
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the mucus barrier in the human body, such as the high secretion of respiratory mucus in common respiratory diseases, makes it difficult for nanoparticles to penetrate effectively, reducing the therapeutic effect of drugs

Method used

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  • Composite nano-microsphere with fast mucus penetration and its preparation method and application
  • Composite nano-microsphere with fast mucus penetration and its preparation method and application
  • Composite nano-microsphere with fast mucus penetration and its preparation method and application

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preparation example Construction

[0061] DETAILED DESCRIPTION OF THE INVENTION The specific embodiments of the present invention also provide a method of preparing a composite nano-microsphere comprising the following steps:

[0062] 1) Metal organic frame ZIF-8 is mixed with black phosphorus quantum dots and the active ingredient to obtain a metal organic frame ZIF-8 aqueous metal organic frame ZIF-8 for negative black phosphorus quantum dots and active ingredients;

[0063] 2) The product obtained by step 1) is surface modified by hydrophilic polymer polymer to obtain a complex nano microsphere;

[0064] The hydrophilic polymer polymer is selected from the group consisting of polyethylene glycol.

[0065] In some embodiments of the invention, the method of surface modification in step 2) is to add a hydrophilic polymer polymer to the aqueous solution obtained, and the excess hydrophilic polymer polymer is removed after mixing. That is.

[0066] In some embodiments of the invention, in step 2), the hydrophilic po...

Embodiment 1

[0086] Example 1 PEG modified and loaded with black phosphorus quantum dots and therapeutic metal organic frame ZIF-8

[0087] This embodiment provides a composite nanopoline with a metal organic frame ZIF-8 as a nano-microsphere body, a composite nano-microspheres, and a black phosphorus quantum dot and therapeutic drug, and the external use of PEG for surface modification. The preparation method is:

[0088] (1) A dispersion of N-methylpyrrolidone and dimethylmethylmethylmes were dispersed in a vacuum environment, and a dispersion of N-methylpyrrolidone and dimethylformamide was dispersed in a mixed solvent of N-methylpyrrolidone and dimethylformamide. Basepyrrholentone and sodium hydroxide are mixed, and then the mixture is heated at 130 ° C for 18 h, cooled to 24 ° C, centrifugally, and collect the supernatant to obtain a black phosphorus quantum dot dispersion;

[0089] (2) The method of preparing metal organic frame ZiF-8 is: It is called 0.31 g of hexahydrate zinc completel...

Embodiment 2

[0092] Example 2 PEG modified and load black phosphorus quantum dots and therapeutic metal organic frame ZIF-8

[0093] A metal organic frame ZIF-8 nano microsphere is prepared, and the method of preparing the preparation method and Example 1 is only in the step (2) step, and 0.2 g of zinc nitrate is replaced by 0.31 g of zinc nitrate, and others remain unchanged. .

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Abstract

The invention relates to a composite nano-microsphere with rapid mucus penetration and its preparation method and application, and specifically discloses a composite nano-microsphere, which includes a metal-organic framework ZIF-8, and a surface modification of the metal-organic framework ZIF-8 The hydrophilic high molecular polymer, the metal organic framework ZIF‑8 is loaded with black phosphorus quantum dots and active ingredients, and the hydrophilic high molecular polymer is selected from polyethylene glycol. In the present invention, for the first time, ZIF-8 is modified with hydrophilic PEG and used to increase its mucus penetration ability, so that the mucus penetration ability of composite nanoparticles is improved, and the targeting ability and ability to penetrate human physiological barrier barriers are improved.

Description

Technical field [0001] The present invention belongs to the technical field of biomedical materials, and more particularly to a composite nanopic ball having a fast mucus penetration and a drug carried release effect, and its preparation method and application thereof. Background technique [0002] Nano-microspheres are generally defined as particles of 1-1000 nm scale, which exhibits a unique property such as a large specific surface area, electromagnetic properties, and optical behavior. Nano microspheres can be artificially regulated in the preparation process, and the nano-microspheres and protective drugs with specific nature are synthesized according to the needs of the drug, and some water soluble drug molecules are dispersed. Prevent it from being discharged from various endogenous defense mechanisms during the in vivo cycle, including enzyme catalytic degradation, immunodegrad, mesh endothelial system, and acid hydrolysis and pulmonary mucosa fibers in the stomach. Furth...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K9/50A61K47/10A61K47/04A61K47/24A61K41/00A61K45/00A61K31/704A61P35/00A61P11/00
CPCA61K49/0067A61K9/5031A61K9/5015A61K9/501A61K41/0042A61K45/00A61K31/704A61P35/00A61P11/00
Inventor 李志斌钱敏喻学锋
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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