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Nano silver bone cement

A nano-silver and bone cement technology, applied in medical science, phosphorus compounds, inorganic chemistry, etc., can solve problems such as low fracture toughness, no PMMA tumor killing effect, and low effective bactericidal concentration

Active Publication Date: 2014-03-12
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] CPC also has many disadvantages: CPC has low fatigue and failure strength in physiological environment, especially in wet environment, the fracture toughness is very low, it is a typical brittle material [Xu HH, Simon CG Jr. Fastsetting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility.Biomaterials, 2005; 26:1337-1348], and CPC has the disadvantages of long curing time and poor adhesion, and CPC does not have the tumor killing effect of PMMA
The antibacterial mechanism of nano-silver is very close to that of silver ions, but the effective bactericidal concentration of nano-silver is significantly lower than that of metallic silver [Elechiguerra J L, Burte J L, Morones J R, et al.Interaction of silvernanoparticles with HIV-1.J Nanobiotechnol , 2005, 3: 6. Kong H, Jang J. Antibacterial properties of novel poly(methyl methacrylate) nanofiber containing silver nanoparticles. Langmuir, 2008, 24: 2051-2056]

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment one novel nano-silver bone cement

[0036] 1. Preparation of strontium-containing calcium phosphate whiskers

[0037] 1) reacting diammonium hydrogen phosphate, sodium lauryl sulfate and sorbitol at a pH value of 2-3 to prepare a phosphorus solution;

[0038] 2) mixing and stirring calcium nitrate, strontium nitrate and urea to fully dissolve the medicine to obtain a strontium-calcium solution;

[0039] 3) Titrate the phosphorus solution with strontium strontium calcium solution, carry out constant temperature reaction at 90-100°C, stop heating after 15h-19h of reaction, cool the reacted solution to room temperature naturally, and age at room temperature for 20h-30h;

[0040] 4) Vacuum filter the solution after aging, add distilled water to filter, and filter until the pH value is 7, then add absolute ethanol, and continue to filter to eliminate residual ions. Dry at a constant temperature for 20 hours at a temperature of 45-70°C. The st...

Embodiment 2

[0053] Antibacterial effect of embodiment two novel nano-silver bone cement

[0054] The antibacterial objects used in the experiment are: standard strain Escherichia coli (ATCC8099), Staphylococcus aureus (ATCC6538).

[0055] The antibacterial test was carried out by the National Film Adhesion Method. The antibacterial test piece is 50mmX50mmX2mm, and the test piece is rinsed with distilled water. After ultraviolet irradiation, add bacterial suspension to each negative and control antibacterial test piece, cover with sterilized PE film, cultivate in a 37°C incubator for 24 hours, count the number of colonies, and repeat the test 3 times, the results are averaged. The average value will be used to calculate the antibacterial rate, and the formula for calculating the antibacterial rate is:

[0056] R(%)=(A-B) / AX100%

[0057] Wherein R is the antibacterial rate (%), A is the negative control group average recovery residual bacteria number (CFU / sheet), B is the experimental grou...

Embodiment 3

[0059] Long-acting bactericidal effect of embodiment three novel nano-silver bone cement

[0060] The antibacterial objects used in the experiment are: standard strain Escherichia coli (ATCC8099), Staphylococcus aureus (ATCC6538).

[0061] The same experimental sample as in Example 2 was prepared, sterilized by ultraviolet radiation, placed in 50 ml sterile normal saline, and replaced with new sterile normal saline once a week. Take it out after 4 weeks, and detect the killing of each sample to Escherichia coli and Staphylococcus aureus according to the method of Example 2.

[0062] The experiment was divided into two groups, the first group was PMMA bone cement, and the second group was the novel nano-silver bone cement of the present invention. Experimental results show that the new nano-silver bone cement of the present invention still has obvious bactericidal effect on Escherichia coli and Staphylococcus aureus after 28 days, so the bone cement of the present invention ha...

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Abstract

The invention discloses novel nano silver bone cement which mainly contains the following components: strontium-containing calcium phosphate whisker, polymethyl methacrylate and nano silver. The diameter of the strontium-containing calcium phosphate whisker ranges from 0.3mum to 2mum; the content of the strontium-containing calcium phosphate whisker is 5%-20% of the bone cement; the Mole ratio of strontium to calcium is 1:30-1:5; and the ratio of the sum of the Mole numbers of strontium and calcium to the Mole number of phosphorus is 1.5-2.0. The novel bone cement contains the nano silver, the content of the nano silver is 0.1%-2%, and the diameter of the nano silver ranges from 5nm to 50nm. The invention describes a preparing method of the novel nano silver bone cement and particularly discloses a preparing method of the strontium-containing calcium phosphate whisker. In addition, the invention further discloses the application of the nano silver bone cement.

Description

technical field [0001] The invention relates to a novel bone cement. Specifically, the present invention prepares a new type of bone cement with good application prospects by modifying polymethyl methacrylate bone cement and calcium phosphate bone cement, combining the biological activity of strontium salt and nano-silver technology. Background technique [0002] Studies have shown that strontium salts have the effect of anti-bone resorption and increasing bone formation. Calcium release was measured in a mouse calvaria culture system and it was found that strontium salts reduced bone resorption by approximately 30%. For mouse dentine cells cultured in long bone cell culture system, strontium salts were found to inhibit the activity of osteoclasts by the same measurement method. In the culture system of rat skull and calvaria, strontium salt initially showed that it can enhance the proliferation of preosteogenic cells, thereby enhancing the activity of functional cells and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/06A61L24/02A61L31/02A61L31/04A61L31/16C01B25/32
Inventor 吴志宏邱贵兴
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI