Sulfydryl-containing tacrine derivative and preparation method and application thereof

A technology of tacrine and its derivatives, applied in medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., to achieve the effects of improving learning and memory, improving learning and memory ability, and overcoming liver toxicity
CN102391180AInactive Publication Date: 2012-03-28HUAZHONG UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUAZHONG UNIV OF SCI & TECH
Publication Date
2012-03-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a sulfydryl-containing tacrine compound or a dynamic isomer or a medicinal salt thereof. The compound or the dynamic isomer or the medicinal salt thereof have the functions of suppressing acetylcholine esterase, enhancing sea horse LTP (Long-Term Potentiation) and improving learning and memory, and can be used for treating, improving or preventing cognitive function decline-related neurous system diseases such as the Alzheimer's disease, vascular dementia, mild cognitive impairment and other oxidative stress participated dementia.
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Description

Technical field

[0001] The invention belongs to the field of medicine and relates to mercaptacrine-containing derivatives and their synthesis methods. The mercaptacrine-containing derivatives of the present invention are mainly used for the treatment of Alzheimer's disease and similar diseases. Background technique

[0002] Alzheimer’s disease (AD), also known as Alzheimer’s disease, is a degenerative disease of the central nervous system characterized by progressive cognitive impairment and impairment of learning and memory. The main pathological characteristics are brain atrophy, Aβ aggregation to form senile plaques, and tau protein hyperphosphorylation to form neurofibrillary tangles. The clinical manifestations are progressive dementia, the cause of which is not yet clear. In recent years, the medical community has proposed a variety of etiological hypotheses, including the cholinergic function decline hypothesis, amyloid deposition hypothesis, oxidative damage hypothe...

Claims

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