Antihypertensive composition containing a ginsenoside-enriched fraction

A technology of ginsenoside and composition, applied in the field of blood pressure-lowering compositions, can solve the problems of small quantity, lack of standardization information of ginsenosides, etc., and achieve the effects of increasing the generation of nitric oxide and preventing hypertension

Inactive Publication Date: 2012-05-23
CJ CHEILJEDANG CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are studies on ginseng extracts, they are small in number and do not provide standardized information centered on ginsenosides, so these studies are limited as functional data on ginseng, ginseng extracts, or ginseng fractions

Method used

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  • Antihypertensive composition containing a ginsenoside-enriched fraction
  • Antihypertensive composition containing a ginsenoside-enriched fraction
  • Antihypertensive composition containing a ginsenoside-enriched fraction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation of ginsenoside concentrated fraction of the present invention

[0029] 1-1: Preparation of ginseng ethanol extract

[0030] Add 70% ethanol to 1 kg of dried tail ginseng, the amount of which is 15 times the weight of the sample, and extract at 70° C. for 24 hours to obtain a ginseng ethanol extract.

[0031] Adopt high performance liquid chromatography (HPLC) to measure the content of ginsenoside Rg1 and Rb1 in the ginseng ethanol extract that obtains, and its result is shown in table 1 and figure 1 .

[0032] 1-2: Preparation of ginsenoside concentrated fraction

[0033] The ethanol extract of ginseng obtained in the above example 1-1 was heated and concentrated to make the Brix degree 80brix. Add distilled water 5 times the weight of the concentrate, fully dilute, and then pass formaldehyde-based HP-20 adsorption resin to absorb saponin components, and continue to pass distilled water about 5 times the volume of the above resin to remo...

Embodiment 2

[0039] Example 2: Preparation of composition tablet for lowering blood pressure containing ginsenoside concentrated fraction of the present invention

[0040] 25 mg of the ginsenoside concentrated fraction obtained in Example 1 was mixed with 270 mg of crystalline cellulose and 200 mg of dextran. Then, 2.5 mg of magnesium and 2.5 mg of hydroxypropylmethylcellulose were added to the above mixture to prepare it.

Embodiment 3

[0041] Example 3: Preparation of the composition capsule for lowering blood pressure containing ginsenoside concentrated fraction of the present invention

[0042] 500 mg of the ginsenoside concentrated fraction obtained in Example 1 was filled into soft gelatin capsule shells, thereby preparing capsules.

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Abstract

The present invention related to an antihypertensive composition containing a fraction enriched with ginsenosides of ginseng. The composition according to the present invention increases the production of nitric oxide through the activation of nitric oxide synthase, and thus exhibits superior antihypertensive effects through the vasodilatory activity. Consequently, the composition of the present invention can be used as a composition for preparing functional health foods for preventing and treating hypertension and various cardiovascular diseases caused by complications of hypertension.

Description

technical field [0001] The present invention relates to a composition for lowering blood pressure containing ginsenoside concentrated fraction, in particular to a composition for lowering blood pressure in which the effective amount of ginsenoside concentrated fraction is 0.1-95% by weight. The invention increases the production of nitric oxide by activating nitric oxide synthase, and has excellent blood pressure lowering characteristics through the expansion of blood vessels. Background technique [0002] According to the National Health and Nutrition Survey in 2005, approximately 27% of males and 21% of females in Korea over the age of 20 suffer from high blood pressure, and more than half of adults over the age of 60 suffer from high blood pressure. Although hypertension has no subjective symptoms, it has a high awareness rate just like arthritis and dental caries. In terms of years, the awareness rate of hypertension among adults over the age of 30 was 27% in 1998, 36% ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P9/12A23L1/30A61K9/14
CPCA23L1/3002A61K31/704A23V2002/00A61K9/0095A61K36/258A23L33/105A61P43/00A61P9/12A23V2250/21A23V2200/326A61K9/14
Inventor 金惠真金世坤李琎熙朴皙浚金英恩权五兰
Owner CJ CHEILJEDANG CORP
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