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Flushing fluid for electrocision and application of same

A technique for surgery and irrigating liquid, applied in the field of medicine, can solve the problem of not being able to meet the treatment of bacterial diseases, etc., and achieve the effects of strong bactericidal activity, infection prevention, and high antibacterial activity

Active Publication Date: 2012-06-13
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the insufficiency and defect that the rinsing solution for electrocution surgery in the prior art cannot satisfy the treatment of bacterial diseases, the present invention provides a kind of irrigating solution for electrocution surgery and its application. Antibacterial effect, because the flushing solution added with quinolones or nitroimidazoles is used as the flushing solution of the bipolar plasma resection system (PKRP), it can perform antibacterial treatment and prevent infection at the same time as the operation, and it contains sodium chloride, It can meet the requirements of the flushing liquid of PKRP as a conductive liquid; moreover, the preparation method is simple, the effect is good, and the stability is good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The rinsing solution for electrocution described in this embodiment contains the following components per 1000ml of rinsing solution:

[0017] Ornidazole 2.5g

[0018] Sodium chloride 8.6g

[0019] Add water for injection to 1000ml

[0020] The preparation method of flushing solution for electrocution operation of the present invention is as follows:

[0021] Concentrated preparation: add fresh water for injection at about 30-40°C and 60% volume to the concentrated preparation tank, start stirring, then slowly add 100% of the prescribed amount of sodium chloride, stir for 5-10 minutes to dissolve; slowly Add 105% of the prescription amount of ornidazole, stir for 20 to 30 minutes to dissolve; add 0.02% (W / V—concentrated volume) of activated carbon, keep warm, stir, and absorb for 20 minutes, filter and remove carbon for 20 to 30 minutes Minutes, after checking the clarification of the medicinal solution, pump the concentrated medicinal solution to the dilute preparat...

Embodiment 2

[0026] The rinsing solution for electrocution described in this embodiment contains the following components per 1000ml of rinsing solution:

[0027] Ofloxacin 2.0g

[0028] Sodium chloride 9.0g

[0029] Add water for injection to 1000ml

[0030] The preparation method of flushing solution for electrocution operation of the present invention is as follows:

[0031] Add 80% volume of fresh water for injection at 55-65°C to the concentrated preparation container. Add an appropriate amount of fresh water for injection into another container, then add the prescribed amount of ofloxacin raw material, stir, and slowly add an appropriate amount of 1mol / L hydrochloric acid dropwise to completely dissolve it. Add the above-mentioned ofloxacin solution into the concentrated preparation container, stir, then add the prescribed amount of sodium chloride raw material, stir until dissolved, and finally add 0.05% (W / V) activated carbon, stir well, keep stirring at 50°C to 60°C Adsorb for...

Embodiment 3

[0033] The rinsing solution for electrocution described in this embodiment contains the following components per 1000ml of rinsing solution:

[0034] Levofloxacin 4.0g

[0035] Sodium chloride 9.0g

[0036] Lactic acid is used in an amount to completely dissolve levofloxacin

[0037] Add water for injection to 1000ml

[0038] The preparation method of flushing solution for electrocution operation of the present invention is as follows:

[0039] Add 80% volume of fresh water for injection at 55-65°C to the concentrated preparation container. Add an appropriate amount of fresh water for injection into another container, then add the prescribed amount of levofloxacin raw material, stir, and slowly add an appropriate amount of 1mol / L lactic acid dropwise to completely dissolve it. Add the above-mentioned levofloxacin solution into the concentrated preparation container, stir, then add the prescribed amount of sodium chloride raw material, stir until dissolved, finally add 0.05...

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PUM

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Abstract

The invention provides flushing fluid for an electrocision and an application of the flushing fluid. The solute of the flushing fluid is quinolone or nitroimidazole drug; the solvent is sodium chloride solution; the concentration of the solute is 0.01 to 50 g / L; the concentration of the sodium chloride is 0.5 to 100 g / L; the quinolone antibiotics contained in the flushing fluid for the electrocision has high antibacterial activity to a plurality of gram negative bacteria and gram positive bacteria, strong function and small side effect; and the nitroimidazole drug has a strong bacterium resisting effect to bacterial cystitis, and has short period of treatment, high curative effect and less untoward effect. The flushing fluid for the electrocision, provided by the invention, can perform bacterium resisting treatment while the electrocision is performed; and the drug is led in through direct current, so that drug ions can reach the position 10 to 15 mm below the skin tissue, has good effect to patients suffering from hyperplastic prostate and accompanied with bacterial prostatitis or cystitis and can prevent residual infection.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a flushing solution for electrocution surgery and its application. Background technique [0002] Benign prostatic hyperplasia (BPH) is a common disease in middle-aged and elderly men. Transurethral resection of the prostate is recognized as the gold standard for surgical treatment of BPH, and the plasma cutting system (PKRP) is the third-generation latest equipment and technology of urological laparoscopic surgery. During electrocution surgery, a large amount of flushing fluid is required to flush the surgical site to keep the field of view clear during the operation and ensure the normal operation process. Since the bipolar plasma must produce effects in the conductive liquid through bipolar means, electrocution surgery is required. The flushing solution must be a conductive solution. Physiological saline solution is the main irrigating fluid available for plasma cutting in clinic at p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K50/00A61K45/00A61K31/4164A61K31/496A61K31/5383A61K31/4375A61P41/00A61P31/04
Inventor 孙怡吴强
Owner HUAREN PHARMACEUTICAL CO LTD
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