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Quality control method for Rosa laevigata root

A quality control method and technology of golden cherry root, applied in medical preparations containing active ingredients, measuring devices, pharmaceutical formulations, etc., can solve problems such as confusion in the application of golden cherry root, and achieve the effect of comprehensive quality control indicators and good stability.

Active Publication Date: 2012-07-11
GUILIN SANJIN PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Golden cherry root, also known as golden cherry scorpion, tuogudan, etc., is the root of the dicotyledonous Rosaceae plant Rosa laevigata Michx. It is mainly produced in Guangdong, Guangxi, Hunan, Jiangxi, Zhejiang, Jiangsu, Anhui and other places. It is wild, and its The nature and taste are sour and astringent, and it has the effect of consolidating essence and astringent intestines. It can be used to treat uterine prolapse, bacillary dysentery, and prolapse of the anus in children. Tablets, Fukeqianjin Tablets, Kuaiying Tea, Jinji Granules, Sanjin Granules, Guangdong Herbal Tea Granules, etc. However, the clinical application of Jinyinggen is rather confusing.

Method used

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  • Quality control method for Rosa laevigata root
  • Quality control method for Rosa laevigata root
  • Quality control method for Rosa laevigata root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048][Determination of content of rosin and rosin] is a newly added test item.

[0049] The inventor found through systematic separation and research that rosin and rosin are the characteristic active ingredients of rosa radix, so it is very necessary to increase rosin and rosin as index components for controlling the quality of this product. This method makes rosin The quality control indicators are more comprehensive.

[0050] 1. Instruments and reagents

[0051] Instruments: Waters 2695 high performance liquid chromatography, evaporative light scattering detector (Alltech-ELSD2000), (Waters996 ultraviolet detector), Empower chromatography workstation.

[0052] Reagents: Methanol is chromatographically pure, water is ultrapure water, and other reagents are analytically pure.

[0053] Reference substance: self-made, because the "Chinese Pharmacopoeia" did not record the chemical reference substances of rosin and rosin, so we separated and prepared rosin and rosin, and foll...

Embodiment 2

[0139] Golden cherry root: golden cherry, Liuzhou, Guangxi

[0140] Determination according to high performance liquid chromatography (Appendix VID of "Chinese Pharmacopoeia").

[0141] Chromatographic conditions and system suitability test: use octadecylsilane bonded silica gel as filler; methanol-water (56:44) as mobile phase; detect with evaporative light scattering detector (or use ultraviolet detector). The number of theoretical plates should not be less than 2000 based on the peak of rosin.

[0142] Preparation of the reference substance solution: take an appropriate amount of rosin and the rosin reference substance (made by the method described in Example 1) respectively, accurately weigh them, add methanol to make a mixed solution containing 0.5 mg per 1 ml, and obtain .

[0143] The preparation of need testing solution: get about 2g of this product powder (passes No. 40kHz) for 45 minutes, let it cool, weigh again, make up the lost weight with 80% methanol, shake w...

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Abstract

The invention relates to a quality control method for Rosa laevigata root. The method is applied to control the mass content of multinoside (C36H58O10) in Rosa laevigata root to be not less than 0.15% and / or the mass content of multiflorin (C36H58O10) to be not less than 0.15%. The method involves determining contents of multinoside and / or multiflorin by HPLC-ELSD. The quality control method for Rosa laevigata root can control complete quality indexes of Rosa laevigata root by determining contents of multinoside and / or multiflorin. The invention first proposes the application of HPLC-ELSD for determining contents of multinoside and / or multiflorin, which is excellent in precision, reproducibility and stability.

Description

technical field [0001] The invention belongs to the field of quality control of Chinese medicinal materials, in particular to a method for quality control of the traditional Chinese medicinal material Rosaceae root. Background technique [0002] Golden cherry root, also known as golden cherry scorpion, tuogudan, etc., is the root of the dicotyledonous Rosaceae plant Rosa laevigata Michx. It is mainly produced in Guangdong, Guangxi, Hunan, Jiangxi, Zhejiang, Jiangsu, Anhui and other places. It is wild, and its The nature and taste are sour and astringent, and it has the effect of consolidating essence and astringent intestines. It can be used to treat uterine prolapse, bacillary dysentery, and prolapse of the anus in children. Tablets, Fukeqianjin Tablets, Kuaiying Tea, Jinji Granules, Sanjin Granules, Guangdong Herbal Tea Granules, etc. However, the clinical application of Jinyinggen is more confusing, if its stems are used as medicine. In order to formulate the quality sta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738G01N30/02G01N30/74A61P1/00A61P15/00A61P31/04
Inventor 邹节明周艳林云强
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD
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