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Traditional Chinese medicine used for treating postmenopausal osteoporosis, preparation method thereof, and administration method thereof

A technology of traditional Chinese medicine and composition, applied in the field of traditional Chinese medicine, can solve the problems of large side effects of western medicine, burden on patients, instability of clinical curative effect, etc., and achieve the effect of high cure rate, convenient administration and low cost

Inactive Publication Date: 2012-07-11
张小林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have a certain curative effect in clinical treatment, but the side effects of Western medicine are relatively large, and the instability of clinical curative effect is also a problem that cannot be solved, which brings a great burden to patients.

Method used

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  • Traditional Chinese medicine used for treating postmenopausal osteoporosis, preparation method thereof, and administration method thereof
  • Traditional Chinese medicine used for treating postmenopausal osteoporosis, preparation method thereof, and administration method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0060] When the dosage form of the Chinese medicine composition of the present invention is a capsule, its preparation method may further comprise the steps:

[0061]In the first step, mix Achyranthes bidentata, Eclipta chinensis and Lycium barbarum according to the stated ratio, add 3 to 5 times of water relative to the mixture to extract the volatile oil, clathrate the obtained volatile oil with β-cyclodextrin, and combine the volatile oil with β-cyclodextrin The ratio of cyclodextrin is 1:7~9, stirring for 40 minutes to 50 minutes, the temperature is 40°C~50°C, and the inclusion compound of volatile oil is obtained, and the water extract is concentrated to a relative density of 1.15~1.17 (60°C) clear ointment;

[0062] The second step is to mix Dipsacus and Ziheche, add ethanol with an alcohol concentration of 55% to 65% relative to the mixture 4 times to 6 times, reflux extraction 2 to 4 times, each time for 2 hours to 3 hours, and filter , the filtrates are combined, eth...

Embodiment 1

[0074] Example 1 Acute toxicity test and long-term toxicity test

[0075] Experimental drug:

[0076] Mix 26g of Achyranthes bidentata, 20g of Eclipta chinensis and 20g of Lycium barbarum, add 200g of water to extract the volatile oil, clathrate the obtained volatile oil with β-cyclodextrin, the ratio of volatile oil to β-cyclodextrin is 1:7, stir For 40 minutes at a temperature of 40°C, the volatile oil clathrate was obtained and set aside; in addition, the water extract was concentrated to a clear paste with a relative density of 1.17 (60°C); 40g Dipsacus and 25g Ziheche were mixed, and the alcohol concentration was 65% 320g of ethanol was refluxed and extracted 3 times, each time for 2 hours, filtered, the filtrates were combined, the ethanol was recovered, concentrated to a clear paste with a relative density of 1.22 (60°C), and set aside; Drain, 15g of licorice and 15g of angelica, add 560g of water, boil for 6 hours, filter, concentrate to a clear paste with a relative ...

Embodiment 2

[0084] Embodiment 2 The capsule prepared by the Chinese medicine composition of the present invention

[0085] Mix 26g of Achyranthes bidentata, 20g of Eclipta chinensis and 20g of Lycium barbarum, add 200g of water to extract the volatile oil, clathrate the obtained volatile oil with β-cyclodextrin, the ratio of volatile oil to β-cyclodextrin is 1:7, stir For 40 minutes at a temperature of 40°C, the volatile oil clathrate was obtained and set aside; in addition, the water extract was concentrated to a clear paste with a relative density of 1.17 (60°C); 40g Dipsacus and 25g Ziheche were mixed, and the alcohol concentration was 65% 320g of ethanol was refluxed and extracted 3 times, each time for 2 hours, filtered, the filtrates were combined, the ethanol was recovered, concentrated to a clear paste with a relative density of 1.22 (60°C), and set aside; Drain, 15g of licorice and 15g of angelica, add 560g of water, boil for 6 hours, filter, concentrate to a clear paste with a r...

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Abstract

The invention provides a traditional Chinese medicine composition used for treating postmenopausal osteoporosis. The medicine composition comprises twotoothed achyranthes root, dipsacus asper, dried human placenta, common burreed tuber, colored mistlitoe herb, yerbadetajo herb, medlar, salvia miltiorrhiza, dragon's blood, licorice root, and ligusticum. When the traditional Chinese medicine composition is used for treating postmenopausal osteoporosis, advantages such as small side effect, good treatment effect, low cost, high curative rate, no medicine resistance, and convenient administration are provided.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating osteoporosis. Background technique [0002] Osteoporosis refers to the absolute reduction of the total amount of bone tissue per unit volume (the ratio of minerals and bone matrix in the bone is normal), which changes the structure and function of the bone, resulting in increased bone fragility, resulting in limbs, low back pain, Systemic skeletal diseases manifested by pathological fractures and body deformation. The disease is mainly divided into primary and secondary types. Primary osteoporosis includes postmenopausal (high conversion type, type I) and senile (low conversion type, type II) osteoporosis. Primary osteoporosis is a modern medical name. In Chinese medicine, the names similar to this disease include atrophy syndrome, bone dryness, bone pole, bone atrophy, etc. Among them, bone atrophy is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/902A61K9/20A61K9/48A61P19/10
Inventor 张小林葛祥成
Owner 张小林
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