Rare earth coordination compound containing Schiff base and bipyridyl and preparation method and bacteriostasis application thereof

A technology of Schiff base and bipyridine, which is applied in the field of rare earth complexes containing salicylaldehyde glycine Schiff base and bipyridine and its preparation, can solve the problems of no unified explanation, etc., and achieve good antibacterial effect and use of rare earth The effect of reducing the amount and widening the application range

Inactive Publication Date: 2012-07-18
INNER MONGOLIA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the antibacterial mechanism of rare earth complexes has been studied for a long time, there is no unified explanation so far.

Method used

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  • Rare earth coordination compound containing Schiff base and bipyridyl and preparation method and bacteriostasis application thereof
  • Rare earth coordination compound containing Schiff base and bipyridyl and preparation method and bacteriostasis application thereof
  • Rare earth coordination compound containing Schiff base and bipyridyl and preparation method and bacteriostasis application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 5mmol of 2,2'-bipyridine and dissolve it in 50mL of methanol, heat to dissolve at 50°C, and under constant stirring, dissolve 50mL of La(NO 3 ) 3 The methanol solution was added dropwise to the above ligand solution, heated and stirred for 1 h. Then 50mL of the methanol solution of salicylaldehyde glycine Schiff base with a concentration of 0.1mol / L was added dropwise to the above reaction system, and the pH value of the system was adjusted to 6 with the methanol solution of potassium hydroxide, and continued heating and stirring for 2h to produce A large amount of precipitation, let stand for 10h. After the solid precipitate was filtered, it was washed several times with methanol, and the obtained solid was dried to constant weight, and the obtained solid powder was the rare earth ternary complex La(Sal-Gly)(Bipy)(NO 3 )·H 2 O products. The element composition analysis results are: experimental value (theoretical value), C%, 40.93 (41.32); H%, 3.41 (3.10); N%...

Embodiment 2

[0024] Weigh 5mmol of 2,2'-bipyridine and dissolve it in 50mL of methanol, heat to dissolve at 60°C, and under constant stirring, add 50mL of Nd(NO 3 ) 3 The methanol solution was added dropwise to the above ligand solution, heated and stirred for 1.5h. Then 50 mL of methanol solution of salicylaldehyde glycine Schiff base with a concentration of 0.1 mol / L was added dropwise to the above reaction system, the pH value of the system was adjusted to 6.5 with methanol solution of potassium hydroxide, and heating and stirring was continued for 2 h to produce A large amount of precipitation, let stand for 10h. After the solid precipitate was filtered, it was washed several times with methanol, and the obtained solid was dried to constant weight, and the obtained solid powder was the rare earth ternary complex Nd(Sal-Gly)(Bipy)(NO 3 )·H 2 O products. Its element composition analysis results are: experimental value (theoretical value), C%, 40.77 (40.93); H%, 3.25 (3.07); N%, 9.59 ...

Embodiment 3

[0026] Weigh 5mmol of 2,2'-bipyridine and dissolve it in 50mL of methanol, heat to dissolve at 65°C, and under constant stirring, add 50mL of Sm(NO 3 ) 3 The methanol solution was added dropwise to the above ligand solution, heated and stirred for 5h. Then 50 mL of methanol solution of salicylaldehyde glycine Schiff base with a concentration of 0.1 mol / L was added dropwise to the above reaction system, the pH value of the system was adjusted to 6.2 with methanol solution of potassium hydroxide, and heating and stirring was continued for 1 h to produce A large amount of precipitation, let stand for 10h. After the solid precipitate was filtered, it was washed several times with methanol, and the obtained solid was dried to constant weight, and the obtained solid powder was the rare earth ternary complex Sm(Sal-Gly)(Bipy)(NO 3 )·H 2 O products. Its element composition analysis results are: experimental value (theoretical value), C%, 40.17 (40.48); H%, 3.22 (3.04); N%, 9.67 (9...

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Abstract

The invention provides a rare earth coordination compound containing a salicylidene glycine Schiff base and bipyridyl and a preparation method thereof. The rare earth coordination compound can be applied to bacteriostasis of colon bacillus. The rare earth coordination compound is characterized in that: the chemical formula of the coordination compound is RE(Sal-Gly)(Bipy)L.H2O, wherein RE is a rare earth ion; Sal-Gly is a salicylidene glycine Schiff base; Bipy is 2,2'-bipyridyl; and L is a negative univalent inorganic negative ion. The preparation method disclosed by the invention has the advantages of easiness and convenience for operating, mild conditions, high controllability, short treatment time and low energy consumption. A rare earth coordination compound bacteriostat has a small using amount of rare earth, and a good bacteriostasis effect is achieved under the synergetic action of rare earth ions and an organic ligand.

Description

technical field [0001] The invention relates to a rare earth organic complex, its preparation method and antibacterial application, in particular to a rare earth complex containing salicylaldehyde glycine Schiff base and bipyridine, its preparation method and antibacterial application. Background technique [0002] In recent years, the research and development of different types of antibacterial agents has made remarkable progress. Among them, the new antibacterial agents represented by rare earth complexes have attracted much attention because of their low toxicity, small side effects and broad-spectrum antibacterial activity. Although the antibacterial mechanism of rare earth complexes has been studied for a long time, there is no unified explanation so far. A generally accepted antibacterial mechanism was proposed by A.Chaudhary. According to this mechanism, after rare earth ions form complexes, the antibacterial effect of the complexes is enhanced because the chelation ...

Claims

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Application Information

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IPC IPC(8): C07F5/00A61K31/555A61P31/04
CPCY02A50/30
Inventor 赵永亮褚海斌李欣孙慧娟
Owner INNER MONGOLIA UNIVERSITY
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