Reverse thermo-sensitivity reversible aquogel composite

A technology of composition and gel, which is applied in the direction of drug combination, active ingredient of hydroxyl compound, drug delivery, etc.

Inactive Publication Date: 2012-08-15
BRODA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the invention is to overcome the limitations of the prior art and meet the needs of users

Method used

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  • Reverse thermo-sensitivity reversible aquogel composite
  • Reverse thermo-sensitivity reversible aquogel composite
  • Reverse thermo-sensitivity reversible aquogel composite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0171] The following are the preparations of hydrogel vehicles including water-soluble block copolymers and associated gel adjuvants at different concentrations:

[0172]

[0173] 1. Solution to gel transition temperature.

[0174] 2. Gel to solution transition temperature.

[0175] 3. From Croda Corporation, Edison, NJ, USA.

[0176] 4. Not measured.

[0177] Preparation method: First, stir and dissolve Pluronic F127 in water at a temperature lower than 10°C. After forming a homogeneous solution, add an associative gel adjuvant to the polymer solution with stirring at around 4°C. All hydrogel compositions formed were clear and transparent.

Embodiment 2

[0179] The following is the preparation of the hydrogel composition for acne treatment:

[0180]

[0181] Preparation method: Mix ingredients A, then add ingredient B with stirring at a temperature lower than 10°C. After forming a homogeneous solution, add component C and continue stirring at room temperature until C dissolves. Add phase D dropwise to the above stirred solution. It forms a clear and transparent hydrogel at room temperature. Formulation I exists as a gel at a temperature ranging from about 9°C to about 30°C, and Formulation II exists as a gel at a temperature ranging from about 0°C to about 38°C.

Embodiment 3

[0183] The following is the preparation of the hydrocortisone hydrogel composition:

[0184]

[0185] Preparation method: Mix ingredients phase A in a beaker, add phase B, and stir at a temperature below 10°C. After a homogeneous solution formed, phase C was added and stirred at room temperature until dissolved. Add Phase D and mix until smooth. Finally, add phase E dropwise and stir until homogeneous.

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Abstract

The invention contains a water soluble block copolymer and a reverse thermo-sensitivity reversible aquogel composite including at least one correlation gel adjuvant. The water soluble block copolymer contains at least two polyethylene oxide blocks and a polypropylene oxide block. The solubility of the correlation gel adjuvant in water is less than 0.5g/100ml and a better choice is less than 0.3g/100ml. The correlation gel adjuvant is able to form water soluble intermolecular complex with water soluble block copolymer. The aquogel composite shows improved gel efficiency and improvement for solubility and/or stability of slightly water soluble and/or water insoluble reagent. The aquogel composite can be applied to various medicine and cosmetic products, such as treatment for esophagus, ear, vagina, rectum, eye and skin diseases and defects.

Description

technical field [0001] The present invention relates to inverse thermosensitive reversible hydrogel compositions applicable to a variety of pharmaceutical and cosmetic products and applications, especially hydrogel compositions applicable locally and / or to mucous membranes, such as esophagus, ear, vagina, rectum, Treatment of eye and skin diseases and imperfections. The invention also relates to methods of making and using such hydrogel compositions, and kits comprising such hydrogel compositions. Background technique [0002] Of course, the fields of application of active ingredients for topical application to humans and animals are wide-ranging, including, for example, the use of active ingredients for pharmaceuticals and cosmetics. It would be particularly desirable to provide such a composition in the form of an inverse thermoresponsive reversible hydrogel that remains in contact with the treatment site and provides controlled or sustained release of the active ingredie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/90A61K8/97A61K8/368A61K9/00A61K47/34A61P17/10A61Q1/00A61Q1/04A61Q5/00A61Q5/10A61Q9/02A61Q9/04A61Q11/00A61Q13/00A61Q15/00A61Q17/02A61Q17/04A61Q19/00
CPCA61K8/042A61K8/86A61K9/0014A61K9/06A61K47/34A61K8/90A61K47/10A61Q17/02A61Q17/04A61Q19/00A61K31/137A61K31/167A61K31/416A61K31/506A61K31/573A61K31/58A61K31/60A61K8/39A61Q1/02A61Q7/00A61Q19/08A61K2800/548C08J3/075C08L71/02C08G2210/00C08G2650/58C08L2203/02A61K47/60A61K8/365A61K31/045A61K2800/10C08G65/329C08G65/332C08G65/3326C08J3/212C08J2371/02A61K8/345A61Q1/12A61K31/565A61K2800/262A61P17/10A61P17/14A61P31/10A61K2300/00A61K8/368A61Q1/00A61Q1/04A61Q5/00A61Q5/10A61Q9/02A61Q9/04A61Q11/00A61Q13/00A61Q15/00A61K8/02A01N25/00A01N37/18A61K8/37A61K47/14A61K2800/54A61K8/33A61Q5/006
Inventor 吕绍祥吕美博
Owner BRODA TECH
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