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Application of ginkgolic acid in pain alleviation

A technology of ginkgolic acid and its use, which is applied in the field of preparing preparations with analgesic effect of ginkgophenolic acid, which can solve the problems of restricting clinical use and the lack of analgesic effect of ginkgophenolic acid, and achieve the improvement of pain threshold, outstanding curative effect, and use Effect without side effects

Inactive Publication Date: 2012-08-22
王青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These disadvantages limit the clinical use of these two classes of analgesics
There is no report on the analgesic use of ginkgolic acid

Method used

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  • Application of ginkgolic acid in pain alleviation
  • Application of ginkgolic acid in pain alleviation
  • Application of ginkgolic acid in pain alleviation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The extraction process of ginkgolic acid from the ginkgo fruit outer testa is as follows: the ginkgo fruit outer testa is peeled off, dried in the sun, and pulverized with a pulverizer. Accurately weigh a certain amount of crushed ginkgo testa, add 80% ethanol with a material-to-liquid ratio of 1:6 (W / V), stir and extract twice at a water bath temperature of 60°C, and extract for 4 hours each time , (Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After the leaching is finished, filter with a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator at a temperature of 55° C. and a pressure of 0.008-0.009 MPa, and concentrate under reduced pressure. Vacuum-dried at 60°C to obtain ginkgolic acid extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water; weighed, and determined the content of ginkgolic acid (mg / g).

...

Embodiment 2

[0029]The extraction process of ginkgo phenolic acid from ginkgo fruit ginkgo is as follows: peel the ginkgo fruit, put it into a tissue grinder, and pulverize it. Accurately weigh a certain amount of pulverized Ginkgo fruit, add 80% ethanol with a solid-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60° C., each extraction time is 4 hours, (Note : After adding liquid, the mouth of the beaker is sealed with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0030] Gi...

Embodiment 3

[0034] The extraction process of ginkgophenolic acid in ginkgo leaves is as follows: cut the ginkgo leaves into pieces, put them into a pulverizer and pulverize them. Accurately take a certain amount of crushed Ginkgo biloba, add 80% ethanol with a solid-liquid ratio of 1:6 (W / V), and stir and extract 2 times at a water bath temperature of 60° C., each extraction time is 4 hours, ( Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0035] Ginkgo...

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Abstract

The invention relates to application of ginkgolic acid in pain alleviation. The ginkgolic acid comprises ginkgo acid, ginkgol, ginkgo diphenol and the like, and can be obtained from an extract of leaves, fruits, testa, rhizomes and the like of ginkgo by a chemical separation method. The pain comprises nerve pain, bone pain, muscle pain, tendon ligament pain, cancer pain and the like. A medicament, a medical instrument, a cosmetic or a disinfectant containing the ginkgolic acid and having a purpose of alleviating pain contains 0.001 to 80 weight percent of ginkgolic acid and pharmaceutically common external preparation matrix or acceptable carrier; and the preparation is any one of pharmaceutical external formulations. Pharmacological experimental research shows that the ginkgolic acid has an obvious effect of improving pain threshold on pain response caused by physical, chemical and cancerous stimulus. Clinical trials show that the ginkgolic acid has a remarkable alleviating effect on various pains and is predominant in curative effect, the effective rate reaches over 95 percent, and the ginkgolic acid is safe in use and does not have side effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the use of ginkgolic acid in preparing preparations with analgesic effect. Background technique [0002] Modern medicine believes that pain is a sensory experience caused by noxious stimuli acting on the body. It is currently one of the common symptoms of most diseases and one of the most common clinical symptoms, and has become a major "killer" that endangers human health. It includes two aspects: one is the pain sensation caused by noxious stimuli acting on the body; the other is the individual's pain response to noxious stimuli, accompanied by strong emotional color and complex psychological activities, manifested as a series of Somatic motor responses and vegetative visceral responses. Whether the tissue damage is caused by disease, inflammation, accidental injury, surgery, ischemia or other reasons, it will produce harmful stimuli, causing the release of pa...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P25/04A61P29/02
Inventor 王青雷红
Owner 王青
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