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Tanshinone lipidosome and preparation method thereof

A technology of tanshinone lipids and liposomes, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, and dressing preparations, etc., can solve the problems of low tanshinone content, inability to directly apply cosmetics, poor water solubility, etc., to increase the content of active substances and protect Good biological activity and stability

Inactive Publication Date: 2012-10-03
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a mild cosmetic grade liposome preparation with high stability and high tanshinone loading content, which solves the problems of poor water solubility, low tanshinone content, and inability to be directly applied to cosmetics in the prior art.

Method used

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  • Tanshinone lipidosome and preparation method thereof
  • Tanshinone lipidosome and preparation method thereof
  • Tanshinone lipidosome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 tanshinone liposome

[0036] Composition formula

[0037]

[0038] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0039] 1. Weigh 2.5 grams of soybean lecithin, 0.4 grams of Tween 60, 8.0 grams of propylene glycol, 0.2 grams of vitamin E acetate, and 0.1 grams of tanshinone into a beaker, and heat in a water bath at 50°C.

[0040] 2. Weigh 88.8 grams of deionized water into a beaker and heat it in a water bath at 50°C.

[0041] 3. Add the water phase to the above system and stir evenly;

[0042] 4. Place the uniformly stirred high-temperature liposome system to cool to obtain liposomes. The particle size of the liposomes measured by photon correlation spectroscopy (PCS) is 10.38um.

Embodiment 2

[0043] The preparation of embodiment 2 tanshinone liposomes

[0044] Composition formula

[0045]

[0046] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0047] 1. Weigh 5.0 grams of egg yolk phospholipids, 1.4 grams of Tween 20, 2.8 grams of propylene glycol, 0.6 grams of vitamin E acetate, and 1.2 grams of tanshinone into a beaker, and heat in a water bath at 50°C.

[0048] 2. Weigh 89.0 grams of deionized water into a beaker, and heat in a water bath at 50°C.

[0049] 3. Add the water phase to the above system and stir evenly;

[0050] 4. The uniformly stirred high-temperature liposome system is left to cool to obtain liposomes, and the particle size of the liposomes is 6.36um as measured by photon correlation spectroscopy (PCS).

Embodiment 3

[0051] The preparation of embodiment 3 tanshinone liposomes

[0052] Composition formula

[0053]

[0054] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0055] 1. Weigh 10.0 grams of egg yolk phospholipids, 3.6 grams of Tween 80, 12.6 grams of propylene glycol, 0.6 grams of vitamin E acetate, and 0.8 grams of tanshinone into a beaker, and heat in a water bath at 50°C.

[0056] 2. Weigh 72.4 grams of deionized water into a beaker, and heat it in a water bath at 50°C.

[0057] 3. Add the water phase to the above system and stir evenly;

[0058] 4. Place the uniformly stirred high-temperature liposome system to cool to obtain liposomes, and the liposomes have a particle size of 0.86um as measured by photon correlation spectroscopy (PCS).

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Abstract

The invention discloses tanshinone lipidosome which takes tanshinone as the carrier and has the effects of resisting bacteria, resisting resistance, removing acne and eliminating acne marks. The tanshinone lipidosome is characterized in that the preparation method of the lipidosome is a propylene glycol injection method and the carrier comprises the following components according to weight percent: 0.01 to 5% of tanshinone, 8 to 25% of emulsifier, 2 to 18% of lecithin, and 0.1 to 1% of antioxidant, and the rest is deionized water, wherein the material of emulsifier is a compound taken from atleast two of the following materials: Tween 20, Tween 60, Tween 80, PEG-200, alcohol, propylene glycol and 1,3-butanediol; the material of lecithin is taken from the following compounds: egg yolk lecithin and soya lecithin; and the antioxidant is vitamin E acetate. The lipidosome preparation agent has good stability and can carry high-content tanshinone; and the preparation method is simple and controllable, has good repeatability and can be applied to cosmetic for removing acne and eliminating acne marks.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetic preparation technology, and relates to a nanoscale carrier and a preparation method thereof, in particular to a preparation method of a liposome with tanshinone as an active ingredient. Background technique [0002] Salvia miltiorrhiza is slightly cold in nature and bitter in taste. It has the effects of promoting blood circulation and removing blood stasis, nourishing blood to calm the nerves, regulating menstruation and relieving pain, cooling blood and eliminating carbuncle. It is a commonly used traditional Chinese medicine for promoting blood circulation and removing blood stasis. Tanshinone (tanshinone) in the traditional Chinese medicine Salvia (SalviamiltiorrhizaBge) content is relatively high, has strong physiological activity, is one of the main active ingredients of Danshen. Studies have shown that tanshinones all contain o-quinone or p-quinone structure, which have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/63A61K8/86A61Q19/02A61P17/00A61P17/10
Inventor 夏强郭星木
Owner SOUTHEAST UNIV
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