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Preparation method of plant-based slow-release compound antibacterial agent for prevention and control of skin ulcer syndrome of Apostichopus japonicus

A compound antibacterial agent, rot skin syndrome technology, applied in the fields of plant/algae/fungus/moss ingredients, antibacterial drugs, plant raw materials, etc. problems, to achieve the effect of promoting food digestion, reducing the amount of drug use, and not producing drug resistance

Inactive Publication Date: 2013-10-23
JINZHOU MEDICAL UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotics are easy to produce residues, which seriously affect the quality and safety of products. At the same time, due to the emergence of drug-resistant strains, the disease is becoming more and more difficult to control
Misuse of disinfectants can pollute the environment and cause stress to sea cucumbers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Using Shewanella yellow sea, a common pathogenic bacterium of A. japonicus rotting skin syndrome in the north, as the model test bacteria, 40 kinds of Chinese herbal medicines derived from plants were screened, and the size of the antibacterial zone was determined; Chinese herbal medicines with good antibacterial effects were selected for the minimum inhibitory concentration test; Composite, then do the orthogonal test; choose the best compound, do the minimum inhibitory concentration test, use the compound to carry out the minimum inhibitory concentration test on other reported A. japonicus rotting skin syndrome pathogens; Toxic reactions; final clinical treatment verification.

[0023] 1. Antibacterial experiment of botanical Chinese herbal medicine

[0024] 1. Preparation of model strains for testing. Shewanella yellowsea is the main pathogen causing rotting skin syndrome of Apostichopus japonicus in the northern coast, provided by the Aquatic Animal Disease Laborat...

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Abstract

A preparation method of plant-based slow-release compound antibacterial agent for prevention and control of skin ulcer syndrome of Apostichopus japonicus includes: taking myrobalan, pomegranate bark, salvia root and clove according to weight ratio of 2:1:1:1, and using clinoptilolite powder accounting for 10% of medicine weight and flour accounting for 5% of the medicine weight as slow-release binding material to prepare the plant-based slow-release compound antibacterial agent. The plant-based slow-release compound antibacterial agent has the advantages that the plant-based slow-release compound antibacterial agent has broad-spectrum and fine effect to common pathogenic bacteria of skin ulcer syndrome of Apostichopus japonicus; combination of the Chinese herbal medicines is reasonable, cooperation and compensation of the medicines are fully utilized, better effect than single medicine is achieved, the clinoptilolite powder and the flour are used as the slow-release binding material, preparation process is simple, cost is low, and the plant-based slow-release compound antibacterial agent is provided with nutrition functions of the clinoptilolite powder and the flour; survival rate and cure rate in clinical application can reach 90% and 85% respectively; and the plant-based slow-release compound antibacterial agent can replace or reduce utilization of antibiotics and disinfectant and has great significance to improving production level pollution-free offspring seeds, guaranteeing food safety, protecting ecological environment, and promoting healthy and sustainable development of Apostichopus japonicus culture industries.

Description

technical field [0001] The invention relates to a method for preparing a plant-derived slow-release compound antibacterial agent for preventing and controlling sea cucumber rot skin syndrome. Background technique [0002] sea ​​cucumber ( Apostichopus japonicus ) belongs to the phylum Echinodermata, the class Holothuridae, and the family Apostichopidae. Naturally distributed in my country's Bohai Sea, Yellow Sea and other waters. It is one of the best quality among more than 20 kinds of edible sea cucumbers in my country. Sea cucumber has extremely high edible and medicinal value. Due to consumers' recognition of its value, the market space is huge, and the market price has remained high. Apostichopus aquaculture is an investment hotspot in recent years and has become an emerging pillar industry of aquaculture in the northern coastal areas of my country. The breeding areas are mainly concentrated in the three provinces of Shandong, Liaoning and Hebei; in recent years, th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/61A61P31/04
Inventor 王维新侯文久杨凤影苏畅
Owner JINZHOU MEDICAL UNIV
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