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Double-cavity dynamic compression column for chromatographic separation

A chromatographic and dynamic compression technology, applied in the field of compression columns, can solve the problems of high price

Active Publication Date: 2014-11-05
江阴市金确分离技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the change of mobile phase during chromatographic separation, the volume of some fillers also changes constantly. Therefore, a dynamic compression column is required so that the column head can change corresponding to the volume change of the filler and keep it close to the filler surface. Currently, large dynamic compression columns With hydraulic system, the price is particularly expensive

Method used

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  • Double-cavity dynamic compression column for chromatographic separation

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Embodiment Construction

[0014] like figure 1 As shown, the present invention has a cylindrical column body 1, a column head 2 is sleeved in the column body 1, and the column head 2 divides the inner cavity of the column body 1 into an upper column cavity 11 and a lower column cavity 12, and the upper column cavity 11 is provided with The feeding port 13, the vacuuming port 14 and the air inlet 18, the feeding port 13 is connected with the column head 2 by a flexible pipe 15 (connected by the prior art structure), and the lower column cavity 12 is provided with a filling port 16 and a liquid outlet Port 17, the lower column cavity 12 is filled with packing 3.

[0015] A seal is provided between the column head 2 and the inner wall of the column body 1. The seal includes a sealing ring 41 made of an elastic material that is pressed against the inner wall of the column body 1. The sealing ring 41 is provided with an annular groove, and the content of the groove is An annular sealing compensating piece ...

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Abstract

The invention provides a double-cavity dynamic compression column for chromatographic separation. The double-cavity dynamic compression column is characterized by comprising a column body, wherein a column head is sleeved in the column body, a seal is arranged between the column head and the inner wall of the column body; the column head partitions the column body to be an upper column cavity and a lower column cavity; the upper column cavity is provided with a feeding opening, an evacuating opening and an air inlet, wherein the feeding opening is connected with the column head by a pipeline; the lower column cavity is provided with a packing inlet and a liquid outlet, wherein the lower column cavity is full of packing. When the double-cavity dynamic compression column is used in a chromatographic separation process, the column head can dynamically raise and fall along with the shrinkage and expansion of the packing so as to cling to a packing level; and the column body and the column head can be manufactured to be great in diameter with acceptable cost.

Description

technical field [0001] The invention belongs to a device for a chromatographic separation instrument, in particular to a compression column used for a chromatographic analysis instrument. Background technique [0002] Chromatographic separation is widely used in the separation of biological, chemical, pharmaceutical, food additives and other monomers. [0003] With the advancement of science and technology, the fillers for chromatography columns are constantly updated, and the cost performance and practicability of chromatography columns are constantly being updated. [0004] During chromatographic separation, the volume of some packings also changes continuously due to the change of the mobile phase, so it is necessary to dynamically compress the column, so that the column head can change according to the volume change of the packing and keep close to the packing surface, while the current large-scale dynamic compression column Using hydraulic system, the price is particul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D15/22
Inventor 於红军
Owner 江阴市金确分离技术有限公司
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