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Antimicrobial compositions and methods

An antibacterial composition, composition technology, applied in botany equipment and methods, antibacterial drugs, drug combinations, etc., can solve problems such as stability limitations

Inactive Publication Date: 2013-01-02
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The fatty acid monoesters in these compositions have limited stability in the presence of other components

Method used

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  • Antimicrobial compositions and methods
  • Antimicrobial compositions and methods
  • Antimicrobial compositions and methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4 and comparative example C1-C8

[0126] Examples 1-4 and Comparative Examples C1-C8: Antimicrobial Efficacy on Hard Surfaces

[0127] Concentrate 1 was prepared by mixing 94 parts by weight PGMC8 and 6 parts by weight DOSS. Example solutions were prepared by diluting concentrate 1 to 0.5-1 wt-% in water containing mannitol or lactoferrin or nisin or colistin, respectively. The proportions of the various enhancers mixed are listed in Table 1 and Table 2. Shake the solution until a milky emulsion forms. Use the emulsion solution immediately after preparation. All final solutions had a pH of 4.5-5. Comparative examples were prepared in the same manner, where no enhancer or antimicrobial lipid was present.

[0128] Table 1. Formulation w / w % for Examples 1-3 and Comparative Examples C1-C6

[0129]

[0130] Table 2. Formulations for Example 4 and Comparative Examples C7 and C8

[0131]

[0132] Inoculum and test procedure:

[0133] From the AOAC Official Method (AOAC Official Method 991.49, 6.2.05) pr...

Embodiment 5-7 and comparative example C9-C10

[0139] Examples 5-7 and Comparative Examples C9-C10: Processing Ground Beef

[0140] Antimicrobial efficacy was analyzed using lactoferrin and nisin as additional enhancers of ground beef treatment.

[0141] Determining native bacterial counts on ground beef

[0142] Purchase ground beef from a grocery store by placing 11-gram (11-g) ground beef in a separate homogenizer bag #6469 filtered with 99 milliliters (mL) of Letheen broth (VWR Scientific, Batavia, IL). (3M, St. Paul, MN) and digested for 1 min in a laboratory agitated Stomacher 400 (Tekmar, Cincinnati, OH) and immediately tested for native bacterial counts. Serial 10-fold dilutions were prepared in Letheen broth. Samples were plated on PETRIFILM Enterobacteriaceae counting plates (EB) (obtained from 3M, St. Paul, MN) and PETRIFILM Aerobic counting (AC) plates (obtained from 3M, St. Paul, MN). Incubate PETRIFILM plates for 24 + / - 2 hours at 35°C and count as recommended on the package insert. Counting plates within...

Embodiment 8

[0154] Example 5 was repeated, noting the following differences. A pressurized sprayer (Sprayer Systems Co., Wheaton, IL) with a flat nozzle was used. Mix Part A (undiluted) and Part B (containing lactoferrin and nisin) using a KITCHEN-AID mixer with a paddle attachment for 3 minutes on low mix setting. The enhancer (Part B) was first delivered at a spray rate of 30 mL / min during the first 1.5 minutes of mixing. In this case, Part A (Concentrate 2) was undiluted and delivered at a spray rate of 7.5 mL / min while continuing to mix for 1.5 minutes (min). Sufficient enhancer and antimicrobial lipids were added to deliver 1 wt-% of concentrate 2 and 4 wt-% of enhancer solution to the meat. Initial native bacteria were 40-80 counts / gram, detected with PETRIFILM AC. After 10 minutes of treatment, native bacteria could not be detected.

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Abstract

The present invention is generally related to a product and process to reduce the microbial contamination on organic matter, such as processed meat, fruits and vegetables, plant parts, inanimate surfaces such as textiles and stainless steel, and in the mouth or on dental products. In particular, the invention is related to a product and process to disinfect surfaces using an antimicrobial composition containing an antimicrobial lipid, an enhancer selected from the group consisting of bacteriocins, antimicrobial enzymes, sugars, sugar alcohols, iron-binding proteins and derivatives thereof, siderophores, and combinations thereof, and optionally a surfactant.

Description

[0001] This application is a divisional application of the international application PCT / US2004 / 029241, which entered the Chinese national phase on April 10, 2006, with the application number 200480029760.X and the title of the invention "antibacterial composition and method". technical field [0002] The present invention generally relates to a composition and method for reducing bacterial contamination on organic matter (such as processed meats, fruits and vegetables, plant parts) and other inanimate surfaces (such as fabrics and stainless steel). Such compositions may also be used, for example, in dental applications to reduce the concentration of bacteria in the mouth. Background technique [0003] Foodborne illnesses cause massive illness and death each year, with some organizations estimating direct and indirect medical costs in excess of $1 billion each. Common food pathogens include Salmonella, Listeria monocytogenes, Escherichia coli 0157:H7, Campylobacter jejuni, B...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/12A01N31/02A01N31/06A01N63/00A01P1/00A01P3/00A61K31/7004A61K31/22A61K31/08A61K38/43A61P1/02A61P31/04A61P31/10A61P31/12A23B4/22A23B4/20A23B7/155A23B7/154A23L3/3571A23L3/3517A23L3/349A01N63/50A01N65/00
CPCA01N37/12A01N31/06A01N31/02A61P1/02A61P31/04A61P31/10A61P31/12A01N63/50A01N65/00A01N61/00A01N59/26A01N43/16A01N43/08A01N37/44A01N37/40A01N37/36A01N37/10A01N37/06A01N37/04A01N37/02A01N31/00A01N31/16A01N2300/00
Inventor 王丹黎马修·T·斯科尔茨苏米塔·B·米特拉巴斯卡尔·V·韦拉马坎尼
Owner 3M INNOVATIVE PROPERTIES CO
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