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Offset 2D separation that adapts 2D gradients to actual 1D conditions

A technology of one part, separation unit, applied in the field of sample separation system

Active Publication Date: 2016-11-09
AGILENT TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Offset 2D separation that adapts 2D gradients to actual 1D conditions
  • Offset 2D separation that adapts 2D gradients to actual 1D conditions
  • Offset 2D separation that adapts 2D gradients to actual 1D conditions

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Embodiment Construction

[0076] In an embodiment of the two-dimensional separation technique, the process of separation in the first dimension is accompanied by continuous or gradual adjustment of parameters along the second dimension. In the following, some basic concepts of the present inventors, on the basis of which the embodiments of the present invention are developed, will be mentioned.

[0077] In an embodiment, a two-dimensional liquid chromatography (2D-LC) system is provided, the second dimension gradient adapted to actual first dimension conditions. That is to say, when running a gradient in the first dimension, the parameters of the second dimension can be offset.

[0078] In two-dimensional chromatography systems, the separate separations are usually optimized independently. In order to optimize the maximum peak capacity (pc), the preferred goal is to achieve an orthogonal separation in two dimensions. Only then, the theoretically achievable maximum pc value is equal to the pc value pc...

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Abstract

The present invention relates to offset two-dimensional separations that adapt second-dimensional gradients to actual first-dimensional conditions. A control device for a sample separation device is provided, comprising a first separation unit and a second separation unit located downstream of the first separation unit and supplied with a fluid sample after being processed by the first separation unit. The control device is configured to: control the first separation unit to perform a primary separation sequence within a time period to separate the fluid sample into fractions; and control the second separation unit to perform a secondary separation sequence within a time period to further divide the separated fractions into fractions; separation into subdivisions, wherein the secondary separation sequence forms part of a common sample separation method defined by a common specification for sample separation comprising a set of parameters; as the primary separation sequence progresses, at least one A parameter upon which at least one of the plurality of secondary separation sequences is performed is performed.

Description

technical field [0001] The present invention relates to sample separation systems. Background technique [0002] In liquid chromatography, a fluid sample and an eluent (liquid mobile phase) can be pumped through a conduit and a column where separation of the sample components takes place. Columns may comprise materials capable of separating different components of a fluid analyte. Packing material (so-called beads, which may include silica gel) can be filled in a column tube, which can be connected to other elements (eg control unit, containers containing samples and / or buffers) via conduits. The composition of the mobile phase can be adjusted by composing the mobile phase from different fluid components with different contributions. [0003] The two-dimensional separation of a fluid sample means performing a first separation process in a first separation unit to divide a fluid sample into a plurality of fractions, and performing a second separation process in a second sep...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06
CPCG01N30/463G01N30/34Y10T436/25375Y10T436/115831G01N30/02
Inventor 克劳斯·威特
Owner AGILENT TECH INC