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Adenosine triphosphate-coenzyme-insulin compound-containing pharmaceutical composition

A technology of adenosine triphosphate and insulin, which is applied in the field of medicine and can solve the problem of large amount of excipients

Active Publication Date: 2013-01-30
罗诚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a kind of adenosine triphosphate coenzyme insulin pharmaceutical composition with good stability and small amount of excipients for the problem of large amount of excipients in the prior art

Method used

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  • Adenosine triphosphate-coenzyme-insulin compound-containing pharmaceutical composition
  • Adenosine triphosphate-coenzyme-insulin compound-containing pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Formula: 20g of adenosine triphosphate, 50000 units of coenzyme A, 4000 units of insulin, 6g of arginine, 405g of dextran, and 3g of NaOH.

[0027] Preparation:

[0028] 1) Dissolve low-molecular-weight dextran in water for injection, add 0.03% (g / ml) activated carbon for injection, boil, cool to 55°C, add arginine, stir to dissolve, filter to remove charcoal, and cool to below 15°C , add adenosine triphosphate, stir and dissolve to obtain solution 1);

[0029] 2) Separately take water for injection and adjust the pH to 5.0 with hydrochloric acid, add coenzyme A, stir and dissolve to obtain solution 2);

[0030] 3) Dissolve NaOH with an appropriate amount of water for injection, control the pH to 9.5, add insulin, stir to dissolve, and obtain solution 3);

[0031] 4) Mix solution 1), solution 2) and solution 3), add water for injection to a total volume of 2000ml, and then filter through a sterilizing filter to a storage tank. After the semi-finished product passes th...

Embodiment 2

[0034] Formula: 25g of adenosine triphosphate, 400,000 units of coenzyme A, 50,000 units of insulin, 4g of arginine, 207g of dextran, and 4g of NaOH.

[0035] 1) Dissolve low-molecular dextran with 250% water for injection, add 0.5% activated carbon for needles, boil, cool to 50°C, add arginine, stir to dissolve, filter to remove carbon, cool to below 15°C, add adenosine triphosphate, Stir and dissolve to obtain solution 1);

[0036] 2) Take another 200 g of water for injection and adjust the pH to 4.8 with hydrochloric acid, add coenzyme A, stir and dissolve to obtain solution 2);

[0037] 3) Dissolve NaOH with 200% water for injection, control the pH to 10.0, add insulin, stir and dissolve to obtain solution 3);

[0038] 4) Mix solution 1), solution 2) and solution 3), add water for injection to 2000ml, then filter to the storage tank through a sterilizing filter, and put the semi-finished product into bottles (1000 pieces) after passing the inspection;

[0039] 5) Put the s...

Embodiment 3

[0041] Formula: Adenosine triphosphate 15g, coenzyme A60000 units, insulin 3000 units, arginine 8g, dextran 40 3g, NaOH2g.

[0042] 1) Dissolve low-molecular dextran in water for injection, add 0.5% activated carbon for needles, boil, cool to 50°C, add arginine, stir to dissolve, filter to remove charcoal, cool to below 15°C, add adenosine triphosphate, and stir Dissolved to obtain solution 1);

[0043] 2) Separately take water for injection and adjust the pH to 4.8 with hydrochloric acid, add coenzyme A, stir and dissolve to obtain solution 2);

[0044] 3) Dissolve NaOH with an appropriate amount of water for injection, control the pH to 9.5, add insulin, stir to dissolve, and obtain solution 3);

[0045] 4) Mix solution 1), solution 2) and solution 3), add water for injection to 2000m, then filter to the storage tank through a sterilizing filter, and put the semi-finished product into bottles (1000 pieces) after passing the inspection;

[0046] 5) Put the subpackaged semi-...

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Abstract

The invention provides an adenosine triphosphate-coenzyme-insulin compound-containing pharmaceutical composition, which comprises the following components: 15-25mg of adenosine triphosphate, 40-60 units of coenzyme A, 3-5 units of insulin, 4-8mg of arginine, 3-7mg of low molecular dextran, and 2-4mg of NaOH. For solutions of different properties, different dissolution strategies are adopted in a preparation process, thus maintaining the efficacy of various drugs as much as possible. By rational allocation of various components of the pharmaceutical composition, the dosages of auxiliary materials are reduced, so that the pharmaceutical composition provided in the invention not only has reduced cost, but also has increased stability and medication safety.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition containing adenosine triphosphate coenzyme insulin compound, and also relates to a preparation method thereof. Background technique [0002] Adenosine triphosphate (ATP) is a nucleotide (also known as adenosine triphosphate), which stores and transmits chemical energy as a substance for energy transmission in cells. Adenosine triphosphate is a coenzyme widely present in the body and is the main source of energy required by tissue cells in the body. The synthesis of proteins, fats, sugars and nucleotides requires the participation of ATP. ATP is catalyzed by adenylate cyclase to form cyclic adenosine monophosphate (cAMP), which is a biologically active substance in cells and plays an important role in regulating many metabolic processes of cells. ATP provides energy for the synthesis of protein, glycogen, lecithin, urea, etc., promotes the repair and regenerat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/28A61K47/04A61K9/19A61P1/16A61P13/12A61P9/04A61K31/7076
Inventor 罗诚
Owner 罗诚
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