Valsartan spray-dried nanosuspension and preparation method of valsartan spray-dried nanosuspension
A nano-suspension, nano-suspension technology, applied in the direction of emulsion delivery, drug combination, cardiovascular system diseases, etc., to achieve the effect of improving bioavailability, less stabilizer dosage, and simple preparation method
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Embodiment 1
[0034] Weigh 1 g of the valsartan raw material drug and dissolve in 10 ml of methanol to form solution A. Separately take 500 mg of Poloxamer 407 and dissolve in 500 ml of double-distilled water to form solution B. The solution B was placed under a magnetic stirring condition of 500 rpm, and then the solution A was quickly injected, and the stirring was continued for 10 minutes to obtain a blue-opalescent valsartan nanosuspension. The average particle diameter of this suspension measured by the Malvern laser particle size analyzer is 155nm, see attached figure 1 .
Embodiment 2
[0036] Weigh 1g of valsartan raw material and 1g of poloxamer 407, add it into 100ml of double-distilled water for high-shear sufficient pre-dispersion, and then transfer it into a high-pressure homogenizer for high-pressure homogenization under the condition of 500bar pressure cycle for 15 times to obtain bluish Chromo-opalescent valsartan nanosuspension. The average particle diameter of this suspension measured by the Malvern laser particle size analyzer is 68nm, see attached figure 2 .
Embodiment 3
[0038] Weigh 1.2g of valsartan crude drug, add 10ml of sodium hydroxide solution (0.6mol / L) to dissolve it, and form solution A. Another 600mg of poloxamer 407 was dissolved in 300ml of hydrochloric acid solution (0.2mol / L) to form solution B. Place B under magnetic stirring, then quickly inject solution A, and continue stirring for ten minutes to obtain a nanosuspension.
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