Methods of improving quality of sleep

A sleep quality and dose technology, applied in the field of improving sleep quality, can solve problems such as not correcting poor sleep quality

Inactive Publication Date: 2013-02-20
THERAVIDA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main limitation of these agents is that they do not correct symptoms of poor sleep quality

Method used

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  • Methods of improving quality of sleep
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  • Methods of improving quality of sleep

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1: Combination of Oxybutynin and Pilocarpine Effects on Sleep in OAB Patients Treated with Oxybutynin sleep quality

[0086] A study was conducted to evaluate the effect of oxybutynin alone, and in combination with pilocarpine (vs. placebo), on sleep quality in a group of patients who have been treated with oxybutynin for at least two months and do not exhibit overt OAB symptom. The aim of this study was to determine sleep quality after oral administration of oxybutynin, alone or in combination with pilocarpine (versus placebo).

[0087] The study was a randomized, crossover, multicentre (seven centres), two sequential and two period study. Approximately 40 subjects (managing their OAB symptoms with immediate-release oxybutynin (5 or 10 mg twice daily)) were randomized to either oxybutynin monotherapy twice daily or twice daily oxybutynin monotherapy. Suboxybutynin combined with pilocarpine for 2 weeks in Phase 1. Subjects were then crossed over to a 2-wee...

Embodiment 3

[0123] Example 3: Combination of tolterodine and pilocarpine for OAB being treated with tolterodine The effect of sleep quality on patients

[0124] The procedure shown in Example 1 was followed except that the patient was treated with tolterodine instead of oxybutynin.

Embodiment 4

[0125] Embodiment 4: the combination of tolterodine and cevimeline is treating OAB patient with tolterodine effect on sleep quality

[0126] The procedure shown in Example 2 was followed except that the patient was treated with tolterodine instead of oxybutynin.

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Abstract

Disclosed herein are methods of treating a patient suffering from overactive bladder (OAB) comprising administering to the patient a combination of antimuscarinic or anticholinergic agent and muscarinic agonist for the treatment of poor quality of sleep in the OAB patient.

Description

[0001] related application [0002] This application claims priority to US Provisional Application No. 61 / 320,208, filed April 1, 2010 by Mehdi Paborji and entitled "Methods of Improving Sleep Quality," the entire contents of which are incorporated herein by reference. technical field [0003] The present invention is in the field of methods of using pharmaceutical compositions to improve sleep quality in antimuscarinic treated patients. Background technique [0004] Patients with overactive bladder (OAB) also complain of poor sleep quality. This may be due to nocturia, or frequent urination at night that disrupts sleep (more than twice a night). It is also possible that there is some biochemical basis for the lack of quality of sleep in these patients. For example, several studies have shown that oxybutynin, tolterodine, and trox have adverse effects on sleep in healthy volunteers. [0005] Several classes of drugs have been used to treat and resolve OAB. A recent evide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/40A61K31/445
CPCA61K31/475A61K31/216A61K31/381A61K31/46A61K31/445A61K31/221A61K31/4025A61K31/4178A61K45/06A61K31/4725A61K31/4174A61K31/137A61K31/215A61K31/439A61K31/222A61K31/185A61P13/00A61P13/10A61P25/20A61P43/00A61K2300/00
Inventor M·帕波吉R·S·弗卢格
Owner THERAVIDA INC
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