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A kind of voglibose tablet and preparation method thereof

A technology of voglibose and sugar tablets, which is applied in the field of voglibose tablets and its preparation, can solve the problems of being unable to meet the huge demand and fewer manufacturers, and achieve the reduction of labor intensity of workers, low production cost and simplicity easy-to-use effects

Active Publication Date: 2017-12-22
SHIJIAZHUANG HUAXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] This product has unique advantages in lowering blood sugar and has a broad market prospect. At the same time, there are few domestic manufacturers, which cannot meet the huge demand for this product from the growing domestic diabetic patients. The research and development and production of this product can reduce the drug burden of patients. , creating greater social benefits

Method used

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  • A kind of voglibose tablet and preparation method thereof
  • A kind of voglibose tablet and preparation method thereof
  • A kind of voglibose tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] prescription:

[0025]

[0026] Preparation:

[0027] (1) Pass the voglibose through a 80-mesh sieve, and pass the filler and lubricant through a 100-mesh sieve for later use.

[0028] (2) Weigh the prescribed amount of voglibose and the filling agent and mix them uniformly by incremental method. Mix the prescribed amount of voglibose with 1% (0.275g) of the prescribed amount of the filling agent (starch) first, Then add 4% (1.1g) of the prescription amount of filler (starch) and mix evenly, then add 10% (2.75g) of the prescription amount of filler (starch) and mix evenly, then add 15% of the prescription amount of filler (starch) (4.125g) mixed well and finally the blended mixture was mixed well with the remaining filler (remaining starch (19.525g) and 100% lactose).

[0029] (3) Add an appropriate amount of binder to make soft materials, granulate with a 20-mesh sieve, dry, pass through a 18-mesh sieve for granulation and set aside.

[0030] (4) Add the prescrib...

Embodiment 2

[0032] prescription:

[0033]

[0034] Preparation:

[0035] (1) Pass the voglibose through a 80-mesh sieve, and pass the filler and lubricant through a 100-mesh sieve for later use.

[0036] (2) Weigh the prescribed amount of voglibose and fillers and mix them evenly by equal volume addition method.

[0037] (3) Add an appropriate amount of binder to make soft materials, granulate with a 20-mesh sieve, dry, pass through a 18-mesh sieve for granulation and set aside.

[0038] (4) Add the prescribed amount of lubricant to the granules, mix for 15 minutes, and press into tablets to obtain the finished product.

Embodiment 3

[0040] prescription:

[0041]

[0042] Preparation:

[0043] (1) Pass the voglibose through a 80-mesh sieve, and pass the filler and lubricant through a 100-mesh sieve for later use.

[0044] (2) Weigh the prescribed amount of voglibose and fillers and mix them evenly by equal volume addition method.

[0045] (3) Add an appropriate amount of binder to make soft materials, granulate with a 20-mesh sieve, dry, pass through a 18-mesh sieve for granulation and set aside.

[0046] (4) Add the prescribed amount of lubricant to the granules, mix for 15 minutes, and press into tablets to obtain the finished product.

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PUM

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Abstract

The invention provides an oral hypoglycemic agent-voglibose tablet and a preparation method thereof. The composition of the tablet is calculated in parts by weight: 1 part of voglibose, 400-800 parts of filler, 30-150 parts of binder, 2-20 parts of lubricant and other components; Pass through the sieve respectively, then mix the sieved materials evenly, add a certain amount of binder to prepare a soft material, add lubricant after granulation and granulation, mix evenly, and press into tablets. The invention improves the stability of the voglibose tablet during storage, and better ensures the safety and effectiveness of medication for patients; at the same time, the preparation process is scientific and reasonable, simple and easy to operate, and has low production cost through production verification. features.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a voglibose tablet and a preparation method thereof which have undergone technological research and verification. Background technique [0002] Voglibose Tablets (trade name: Basen) is a new generation of α-glucosidase inhibitors developed by Takeda Pharmaceutical Co., Ltd. in Japan. It was first launched in Japan in 1994 under the trade name Basen and in Korea in 1998. It was launched in China in 1999. The domestic manufacturer is mainly Tianjin Takeda, and the trade name is "Bexin". In addition, this product and pioglitazone (pioglitazone) form a compound to improve glucose tolerance, which is undergoing phase III clinical trials in Japan, and is suitable for lowering blood sugar after meals. Preclinical and clinical studies have shown that the pharmacological effect of the drug is to inhibit the disaccharide hydrolase in the small intestine by competitively inhibiting the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/133A61P3/10
Inventor 张硕王敏马海波李明海张云郭卿
Owner SHIJIAZHUANG HUAXIN PHARMA
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