The invention discloses a Chinese medicine composition for dissolving thrombus and a preparation method thereof. The Chinese medicine composition is prepared from, by weight, 5-20 parts of garter snake, 5-10 parts of chuanxiong rhizome, 3-10 parts of lumbricus, 5-10 parts of roots of caragana sinica, 5-20 parts of angelica sinensis, 5-20 parts of oil cassia, 3-10 parts of schefflera arboricola, 5-10 parts of manis pentadactyla, 5-20 parts of radix salviae miltiorrhizae, 5-20 parts of radix scrophulariae, 5-10 parts of licorice root, 10-15 parts of inula nervosa wall, 5-20 parts of radix cyathulae, 5-20 parts of honeysuckle flower, 5-10 parts of gecko, 5-20 parts of fructus arctii, 5-20 parts of radix notoginseng, 5-20 parts of frankincense, 5-20 parts of herba erigerontis, 10-15 parts of ampelopsis grmsedntarac and 5-20 parts of gecko. The combination of various medicine of the Chinese medicine composition can dissolve thrombolysis and remove blood stasis, warm and smooth blood vessels, dredge collaterals and remove dampness, promote blood circulation to remove blood stasis, relieve swelling and pain, strengthen body resistance and eliminate evil, has obvious effects of activatingblood, removing blood stasis and dissolving thrombus, has effects of lowering blood lipids, warming and smoothing meridians and collaterals, inhibiting the formation of thrombus, preventing the stagnation of the meridians and collaterals, and alleviating the numbness of the shoulder, neck and limbs and the like, and has a significant effect on preventing and treating diseases caused by thrombus.