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Gastrodin injection liquid and preparation method thereof

A technology of gastrodin injection and gastrodin, applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of instability of gastrodin aqueous solution and the inability to ensure the safety and effectiveness of medication for patients and other issues to achieve the effects of stable properties, drug safety, and product quality assurance

Inactive Publication Date: 2013-06-19
SHANDONG FANGMING PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to the instability of the gastrodin aqueous solution, the produced gastrodin injection will often precipitate a large number of white spots and white lumps during storage after being sterilized, and will continue to increase during the storage process, which cannot guarantee the safety of medication for patients. ,efficient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Prescription: Gastrodin 100g

[0026] EDTA-2Na 0.1g

[0027] NaCl 8g

[0028] Add water for injection to 1000ml

[0029] Made 500

[0030] Phosphate buffer solution with pH 7.8 was first prepared for later use. Take 70% of fresh water for injection and add it to the concentrated preparation tank, cool to 35-40°C, add the prescribed amount of EDTA-2Na into it, stir to dissolve it, then add the prescribed amount of gastrodin, stir to dissolve it completely, and then Add the prescribed amount of sodium chloride to the solution, stir and mix evenly, adjust the pH value to 6.2 with a phosphate buffer solution of pH 7.8, weigh the medicinal charcoal with a preparation amount of 0.1%, add it to the concentrated tank, and add water for injection To the full amount, stir and let it stand for 15 minutes to absorb, filter and decarburize to dilute the tank, then filter and sterilize through a 0.22um microporous filter element, then potting, sterilize in a...

Embodiment 2

[0032] Prescription: Gastrodin 100g

[0033] EDTA-2Na 0.2g

[0034] NaCl 8g

[0035] Add water for injection to 1000ml

[0036] —————————————————

[0037] Made 500

[0038] Phosphate buffer solution with pH 7.8 was first prepared for later use. Take 70% of fresh water for injection and add it to the concentrated preparation tank, cool to 35-40°C, add the prescribed amount of EDTA-2Na into it, stir to dissolve it, then add the prescribed amount of gastrodin, stir to dissolve it completely, and then Add the prescribed amount of sodium chloride to the solution, stir and mix evenly, adjust the pH value to 6.3 with a phosphate buffer solution of pH 7.8, weigh the medicinal charcoal with a preparation amount of 0.1%, add it to a concentrated tank, and add water for injection To the full amount, stir and let it stand for 15 minutes to absorb, filter and decarburize to dilute the tank, then filter and sterilize through a 0.22um microporous filter element, th...

Embodiment 3

[0040] Prescription: Gastrodin 100g

[0041] EDTA-2Na 0.2g

[0042] NaCl 8.5g

[0043] Add water for injection to 1000ml

[0044] —————————————————

[0045] Made 500

[0046] Phosphate buffer solution with pH 7.8 was first prepared for later use. Take 70% of fresh water for injection and add it to the concentrated preparation tank, cool to 35-40°C, add the prescribed amount of EDTA-2Na into it, stir to dissolve it, then add the prescribed amount of gastrodin, stir to dissolve it completely, and then Add the prescribed amount of sodium chloride to the solution, stir and mix evenly, adjust the pH value to 6.3 with a phosphate buffer solution of pH 7.8, weigh the medicinal charcoal with a preparation amount of 0.1%, add it to a concentrated tank, and add water for injection To the full amount, stir and let it stand for 15 minutes to absorb, filter and decarburize to dilute the tank, then filter and sterilize through a 0.22um microporous filter element, ...

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PUM

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Abstract

The invention discloses gastrodin injection liquid and a preparation method thereof, in particular to gastrodin injection liquid containing gastrodin, water for injection, a metal ion complexing agent, and an injection liquid stabilizing agent and the preparation method thereof. The metal ion complexing agent is added to the injection liquid to avoid oxidization of the gastrodin. The stabilizing agent which is sodium chloride is added to the injection liquid to avoid precipitation of the gastrodin in the injection liquid, guarantee stability of the gastrodin injection liquid, prevent occurrence of white points and white blocks in the injection liquid, guarantee quality of products and safety and effects of medicine use for patients.

Description

technical field [0001] The invention relates to a gastrodin injection and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Gastrodin is the dry tuber root extract of the orchid plant Gastrodia elata. Gastrodin has good sedative and hypnotic effects, and can relieve neurasthenia, insomnia, and headache symptoms. The traditional Chinese medicine Gastrodia elata can treat dizziness, numbness, and convulsions. Clinical application: treatment of vertebral-basilar artery insufficiency; treatment of vestibular neuronitis; treatment of vertigo. [0003] When gastrodin is used clinically as an injection, the existing routes of administration are intramuscular injection or intravenous infusion, and visible foreign matter is the focus of water needle inspection. If visible foreign matter is unqualified, injecting it into the patient's body will give the patient It causes pain, and some even form granulation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7034A61K47/48A61K47/04A61K47/18A61P25/20A61K47/54
Inventor 沈红宾靳奉会吴双俊王飞龙尚艳军李广利
Owner SHANDONG FANGMING PHARMACEUTICAL CO LTD
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