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Navel patch for treating infantile dyspepsia and preparation method thereof

A technology for children with dyspepsia and umbilical sticking, which is applied to the digestive system, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve problems such as inconvenient taking, liver first-pass effect, and poor compliance. To achieve the effect of convenient medication, prolonging the treatment time and avoiding degradation

Inactive Publication Date: 2021-02-05
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide an umbilical patch for treating dyspepsia in children and a preparation method thereof, aiming at problems such as poor medication compliance of existing oral preparations for children, inconvenient taking, liver first-pass effect, etc.

Method used

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  • Navel patch for treating infantile dyspepsia and preparation method thereof
  • Navel patch for treating infantile dyspepsia and preparation method thereof
  • Navel patch for treating infantile dyspepsia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method of an umbilical patch for treating dyspepsia in children, comprising the following steps:

[0032] 1) Preparation of the extracts of spider incense and woody incense: add ethanol with a mass concentration of 70% to the spider incense and woody fragrance respectively, according to 8 times the mass of spider incense and woody fragrance, perform the first reflux extraction, filter Obtain the filtrate, then add 80% ethanol with a mass concentration of 80% ethanol to the filter residue according to 6 times the quality of spider incense and woody fragrance, carry out the second reflux extraction, filter, combine the 2 filtrates, and under the temperature condition of 50 ℃, reduce pressure Concentrate the filtrate to 2g crude drug / mL, reclaim ethanol, and obtain the extracts of Aranthus chinensis and Fragrance argentina respectively;

[0033] 2) Preparation of Tsaoko extract: add 13.5 times of Tsaoko’s mass in distilled water to Tsaoko, soak for 2 hours, d...

Embodiment 2

[0043] A preparation method of an umbilical patch for treating dyspepsia in children, comprising the following steps:

[0044] 1) Preparation of the extracts of spider incense and woody incense: add ethanol with a mass concentration of 70% to the spider incense and woody fragrance respectively, according to 8 times the mass of spider incense and woody fragrance, perform the first reflux extraction, filter Obtain the filtrate, then add 80% ethanol with a mass concentration of 80% ethanol to the filter residue according to 6 times the quality of spider incense and woody fragrance, carry out the second reflux extraction, filter, combine the 2 filtrates, and under the temperature condition of 55 ℃, depressurize Concentrate the filtrate to 2g crude drug / mL, reclaim ethanol, and obtain the extracts of Aranthus chinensis and Fragrance argentina respectively;

[0045] 2) Preparation of Tsaoko extract: add 13.5 times the mass of Tsaoko in distilled water, soak for 4 hours, distill and ...

Embodiment 3

[0055] A preparation method of an umbilical patch for treating dyspepsia in children, comprising the following steps:

[0056] 1) Preparation of the extracts of spider incense and woody incense: add ethanol with a mass concentration of 70% to the spider incense and woody fragrance respectively, according to 8 times the mass of spider incense and woody fragrance, perform the first reflux extraction, filter Obtain the filtrate, then add 80% ethanol with a mass concentration of 80% ethanol to the filter residue according to 6 times the quality of spider incense and woody fragrance, carry out the second reflux extraction, filter, combine the 2 filtrates, and under the temperature condition of 52 ℃, depressurize Concentrate the filtrate to 2g crude drug / mL, reclaim ethanol, and obtain the extracts of Aranthus chinensis and Fragrance argentina respectively;

[0057] 2) Preparation of Tsaoko extract: add 13.5 times of Tsaoko’s mass in distilled water to Tsaoko, soak for 3 hours, dist...

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Abstract

The invention provides a navel patch for treating infantile dyspepsia and a preparation method thereof. The navel patch is composed of a matrix and a medicine; the medicine is prepared from the following components in parts by mass: 10-30 parts of valeriana jatamansi jones extract, 3-10 parts of radix aucklandiae extract and 5-20 parts of amomum tsao-ko extract; the matrix is prepared from the following components in parts by mass: 0.1-0.4 part of lecithin, 0.01-0.03 part of cholesterol, 0.01-0.05 part of sodium cholate, 0.3-0.9 part of propylene glycol, 0.3-1 part of dihydroxyaluminium aminoacetate, 10-40 parts of glycerinum, 5-20 parts of NP700, 0.5-2 parts of tartaric acid and 2-6 parts of PVPK90. The medicine is administrated through the navel, medication is convenient and effective, the first-pass effect of liver is avoided, drug absorption is not affected by gastrointestinal tract factors, medication safety is improved, the navel patch has a sustained and controlled release effect, constant blood concentration is formed in a navel, and the navel patch is beneficial to prolonging the treatment time of the medicine.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to an umbilical patch for treating infantile dyspepsia and a preparation method thereof. Background technique [0002] Children's spleen and stomach health is a hot spot that people have been paying attention to. Functional dyspepsia is a common and frequently-occurring disease in pediatrics, which affects children's physical and mental health, learning and quality of life. Functional dyspepsia belongs to the categories of "fullness", "epigastric pain", "hiccups", "noisy", "indigestion" and "food accumulation". It is currently considered to be the result of multiple factors, mainly including food intolerance and abnormal gastrointestinal motility , visceral hypersensitivity, abnormal gastric acid secretion, and mental and psychological factors. [0003] Traditional Chinese medicine believes that children with weak spleen and stomach, me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/70A61P1/14
CPCA61K36/84A61K36/285A61K36/9064A61K9/7023A61K47/32A61P1/14A61K2236/333A61K2236/39A61K2236/331A61K2236/51A61K2300/00
Inventor 马云淑梅佳华孙杏倩普娟蔡俊飞刘云宽高家菊
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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