Liquid wound repairing film and preparation method thereof

A wound and liquid technology, applied in the field of liquid wound repair film and its preparation, can solve the problems of difficult to provide moist skin cell proliferation, wound healing, poor biocompatibility and biosafety, dust or water infiltration into the wound, etc. Restoration of appearance and function, good biocompatibility, prevention of skin cracking

Active Publication Date: 2013-04-03
ARNOKANG NINGXIA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the products used for wound repair in the medical field, such as various wound plasters, have the advantages of low price and convenient use, and are often regarded as simple and easy wound treatment products. However, traditional wound plasters have the following disadvantages: (1) Poor air permeability , does not have the effect of waterproof and breathable; (2) It is poorly worn with the wound, and the wound is often fixed on the wound through the adhesive layer. The seal between the wound and the outside world is poor, and it is easy for dust or water to seep into the wound, making the wound infected and the scar too large; ( 3) All kinds of existing bandages have a fixed size, which is inconvenient to use on some specific wound sites
Of course, there are also researches on liquid bandages and products on the market at present, mainly mixing active ingredients that promote wound repair with film-forming chemicals, which has poor biocompatibility and biosafety. wound healing

Method used

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  • Liquid wound repairing film and preparation method thereof
  • Liquid wound repairing film and preparation method thereof
  • Liquid wound repairing film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] Preparation of carboxymethyl chitosan: take 10.0 g of chitosan in a three-necked flask, add 100 mL of isopropanol, stir at 50-60 °C for 10 min, and divide 10 mol / L NaOH 25 mL solution into 5 batches for 20 minutes under stirring After adding, stir for 10 min, set it to swell at room temperature for 12-15 h, add 60 g of chloroacetic acid to the swollen chitosan in 5 batches, then heat up to 60 °C, continue stirring for 3 h and then stop, vacuum filtration, filter residue After being washed with ethanol for many times, the carboxymethyl chitosan was obtained by drying at 50° C. and stored in a desiccator.

[0027] Infrared spectral analysis: KBr tablet was used, Avatar 370 Fourier transform infrared spectrometer was used to measure the prepared carboxymethyl chitosan, and the result was shown in the IR spectrum at 1635.56cm -1 and 1385.22cm -1 The characteristic absorption peak of carboxymethyl sodium salt appeared at the place, indicating that the carboxymethylation rea...

Embodiment 1

[0041] Bottom liquid preparation: The CMC physiological saline solution with a concentration of 0.5 mg / mL prepared in the screening example was used as the bottom liquid.

[0042] Preparation of film liquid: Weigh 1.5 g of polyvinyl butyral, measure 30 mL of 80% ethanol, heat and stir in a three-necked flask, and after the film-forming substance is completely dissolved, the film liquid as a liquid wound-stick is obtained.

[0043] When using, first apply the base liquid on the wound, and then apply the film liquid. The membrane liquid coated on the surface dries within 90s, which can effectively maintain the moist and sterile environment of the bottom liquid and provide good conditions for wound healing.

Embodiment 2

[0045] Bottom liquid preparation: The CMC physiological saline solution with a concentration of 1.0 mg / mL prepared in the screening example was used as the bottom liquid.

[0046] Preparation of film liquid: weigh 3.5 g of polyvinyl butyral, 0.3 g of chitosan, and 35 mL of 95% ethanol, heat and stir in a three-necked flask, and after the film-forming substance is completely dissolved, add glycerol 1mL was mixed and stirred evenly to obtain a membrane liquid, and the stirring speed was 300-400 rpm. The resulting membrane fluid is used as a liquid wound dressing.

[0047] Smear the membrane liquid on the glass, tear it off after forming the membrane, and weigh 0.1 g, put it into 100 mL of phosphate buffer solution to simulate gastric simulated intestinal fluid (pH 7.45), stir at 37 °C at a speed of 100 rpm, and release for 180 min. 2mL of solution was drawn from it at regular intervals to determine the content of chitosan, and the same volume of phosphate buffer solution was su...

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Abstract

The invention discloses a liquid wound repairing film and a preparation method thereof. The liquid wound repairing film comprises a base solution and a film solution, wherein the base solution is a physiological saline solution of carboxymethyl chitosan (CMC); the concentration of the carboxymethyl chitosan in the base solution is 0.5-5.0 mg / mL; the film solution comprises polyvinyl butyral (PVB) and an ethanol solution; the concentration of the ethanol solution is 80-100%; and the using amount of the polyvinyl butyral is 0.5-1.7 g in every 10mL of the ethanol solution. The liquid wound repairing film has the characteristics of quickness in drying, water tightness, breathability, bacterial resistance and the like, and is high in bio-safety and accurate in therapeutic effect.

Description

technical field [0001] The invention relates to a liquid wound repair film and a preparation method thereof. Background technique [0002] At present, products used for wound repair in the medical field, such as various wound dressings, are often regarded as simple and easy wound treatment products due to their advantages of low price and convenient use. However, traditional wound dressings have the following disadvantages: (1) Poor air permeability , does not have the effect of waterproof and breathable; (2) It is poor in clothing with wound stickers, and the wound stickers are often fixed to the wound through the adhesive layer, the wound is poorly sealed with the outside world, and it is easy for dust or water to infiltrate the wound, causing the wound to become infected and the scar is too large; ( 3) Various existing band-aids have a fixed size, which is inconvenient to use for some specific wound sites. Therefore, if the traditional band-aid is used improperly, it wil...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/24A61L15/20A61L15/42
Inventor 顾海鹰夏栋林李晓东何红王雨飞陈超陈燕培
Owner ARNOKANG NINGXIA BIOTECH
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