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A method for extracting cistanche glucoside from Cistanche cistanche

A technology of cistanche glycosides and cistanche glycosides, which is applied in chemical instruments and methods, preparation of sugar derivatives, production of bulk chemicals, etc., can solve the problems of low extraction rate and low extraction purity, and achieve large adsorption capacity , good thermal stability, rich source of raw materials

Inactive Publication Date: 2015-12-23
DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of conventional techniques such as relatively low extraction rate and low extraction purity, and to provide a method that utilizes supercritical CO 2 Method for Enrichment and Purification of Cistanche Glycosides in Herba Cistanche by Fluid Extraction and Macroporous Adsorption Resin Coupling Method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0017] Implementation Case 1: A method using supercritical CO 2 The method for enriching and purifying cistanche glycosides in Cistanche cistanche by fluid extraction and macroporous adsorption resin coupling method, the steps are as follows:

[0018] (1) Crush 500g of hay cistanche and pass through a 60-mesh sieve, add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the entrainer accounts for 1% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 50°C, and the CO 2 The flow rate is 1mg / g crude drug min, and the extraction time is 100min to obtain the extract;

[0019] (2) adjusting the pH value of the Cistanche deserticola extract treated in step (1) to 3.0 with hydrochloric acid, leaving it to stand, suction filtration, and concentrating under reduced pressure to obtain the crude extract of Cistanche deserticola glucoside;

[0020] (3) The obtained cistanche glucoside crude extract is adsorbed with a mac...

Embodiment example 2

[0025] Implementation Case 2: A method using supercritical CO 2 The method for enriching and purifying cistanche glycosides in Cistanche cistanche by fluid extraction and macroporous adsorption resin coupling method, the steps are as follows:

[0026] (1) Crush 500g of hay cistanche and pass through a 70-mesh sieve, and add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the entrainer accounts for 2% by volume of the total extraction solvent, the extraction pressure is 30MPa, the temperature is 55°C, and the CO 2 The flow rate is 2mg / g crude drug min, and the extraction time is 120min to obtain the extract;

[0027] (2) adjusting the pH value of the Cistanche deserticola extract treated in step (1) to 3.8 with hydrochloric acid, standing, suction filtering, and concentrating under reduced pressure to obtain the crude extract of Cistanche deserticola glucoside;

[0028] (3) The obtained cistanche glucoside crude extract is adsorbed with a macroporous...

Embodiment example 3

[0033] Implementation Case 3: A method using supercritical CO 2 The method for enriching and purifying cistanche glycosides in Cistanche cistanche by fluid extraction and macroporous adsorption resin coupling method, the steps are as follows:

[0034] (1) Crush 500g of hay cistanche and pass through an 80-mesh sieve, and add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, and the volume percentage of the entrainer in the total extraction solvent is 3%, the extraction pressure is 40MPa, the temperature is 60°C, and the CO 2 The flow rate is 3mg / g crude drug min, and the extraction time is 140min to obtain the extract;

[0035] (2) adjusting the pH value of the cistanche cistanche glucoside extract to 4.0 with hydrochloric acid, standing, suction filtration, and concentrating under reduced pressure to obtain the cistanche cistanche glucoside crude extract;

[0036] (3) The obtained cistanche glucoside crude extract is adsorbed with a macroporous adsor...

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Abstract

The invention belongs to the field of natural organic chemistry, and relates to a method for enriching and purifying boschniakia rossica glucoside in boschniakia rossica through supercritical CO2 fluid extraction and macroporous resin coupling. The method has the characteristics that effective components of a medical plant are kept in an extraction process by a supercritical CO2 fluid extraction technology; chemical reaction does not occur in the extraction process; the safety is good; the extraction efficiency is high; the energy consumption is less; the production efficiency is improved; and the cost is lowered. With the adoption of a macroporous adsorbing technology for separating and purifying boschniakia rossica glucoside, a separating effect is obvious; the extraction purity is high; semifinished boschniakia rossica glucoside with the content above 30%, and finished boschniakia rossica glucoside with the content above 95% can be obtained; and the defects that the conventional extraction yield is relatively lower and the extraction purity is low are overcome.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry and relates to a method for purifying cistanche glycosides, in particular to a method for using supercritical CO 2 A method for enriching and purifying cistanche glycosides in Cistanche cistanche by fluid extraction and macroporous adsorption resin coupling method. Background technique: [0002] Cistanche cistanche is the whole herb of Cistanche cistanche cistanche, an annual parasitic herb. The whole plant contains 8-epideoxyloganic acid (8-epideoxyloganic acid), rossicaside (rossicaside) B, C, D, rossicaside A, rossicaside (boschnaside) , cistanche aldoside (boschnaloside), pinoresinol-β-D-glucopyranoside (pinoresinol-β-D-glucopyranoside), p-coumaric acid (p-coumaric acid), p-coumaric acid methyl ester ( methylp-coumarate), β-sitos-terol, oleanolic acid, 3-epioleanolic acid, β-D-glucopyranosyl (1→4 )α-rhamnopyranosyl-(1→3)-D-(4-O-caffeoyl)glucopyranosyl (β-D-glucopyranosyl(1→4)-α-L-r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/04C07H1/08
CPCY02P20/54
Inventor 万莉姚德坤张亚红姚德利
Owner DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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