Application of anthracene nucleus antibiotic and its pharmaceutical salt for treating neovascular glaucoma
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of new blood vessels and antibiotics, applied in the direction of drug combinations, pharmaceutical formulas, organic active ingredients, etc., can solve problems such as reducing the quality of life of patients
Active Publication Date: 2013-06-26
张雅珍
View PDF0 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Due to its blinding properties, it will seriously reduce the patient's quality of life
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0021] ① Take 300mg of poly(lactic-co-glycolic acid) (PLGA) and add it into 1ml of dichloromethane to prepare a solution;
[0022] ② Add 50 mg of arubicin to the solution prepared in ①, and mix well by ultrasonic;
[0023] ③Use a syringe to slowly inject the solution in ② into the cottonseed oil containing 0.05% egg yolk oil, stir at 1000r / min for 20min, then reduce the speed to 200r / min and continue stirring for 4h;
[0024] ④Add 20ml petroleum ether to step ③, centrifuge at 8000r / min for 5min after 30min;
[0025] ⑤ Collect the microspheres, wash with petroleum ether and evaporate to dryness.
Embodiment 2
[0027] ① Take 200mg PLGA and add it to 1ml tetrahydrofuran solution to prepare a solution;
[0028] ② Add 50 mg of mitoxantrone to 0.2 ml of glycerin, mix well and add to the solution prepared in ①, stir with a homogenizer for 1 min to obtain colostrum;
[0029] ③Add it to 12ml of 2% polyvinyl alcohol (PVA) solution, stir at 1000r / min for 5min, then add 120ml of 0.5%PVA solution to obtain double emulsion;
[0030] ④ Reduce the rotational speed to 200r / min and continue stirring for 4h, then centrifuge at 8000r / min for 5min;
[0031] ⑤ The microspheres were collected, washed with distilled water and freeze-dried.
Embodiment 3
[0033] ① Take 100mg of PSA-PEG and add it to 1ml of dichloromethane solution to prepare a solution;
[0034] ② Add 50 mg of arubicin to the solution prepared in ①, and mix well by ultrasonic;
[0035] ③ Add the solution prepared in ② into 15ml 1% PVA solution;
[0036] ④ Reduce the rotational speed to 200r / min and continue stirring for 4h, then centrifuge at 8000r / min for 5min;
[0037] ⑤ Collect microspheres, wash with distilled water and collect.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses an application of anthracene nucleus antibiotic and its pharmaceutical salt for treating neovascular glaucoma. The invention found that the anthracene nucleus antibiotic and its pharmaceutical salt have good effect on treatment of r neovascular glaucoma, and especially the anthracene nucleus antibiotics can be prepared to prolonged action preparations such as a nano preparation, a microballoon preparation, liposome and hydrogel, the toxicity of anthracene nucleus antibiotic is reduced, and the anthracene nucleus antibiotic enables ophthalmic administration, administration dosage is simultaneously enlarged, the duration time of drug effect is long, the medicament curative effect is stronger than that of the common preparations of the anthracene nucleus antibiotic, when the ophthalmic administration is carried out, the anthracene nucleus antibiotic has good treatment effect for treating retinal vein occlusion, and the blank that no medicine is good for treating neovascular glaucoma can be filled.
Description
technical field [0001] The present invention relates to a medicine for treating neovascular glaucoma, in particular to the new application of a series of traditional antitumor antibiotics anthracyclines and pharmaceutically acceptable salts thereof in the preparation of medicines for treating neovascular glaucoma, in particular, the anthracene Cyclic antibiotics and their pharmaceutically acceptable salts are prepared into long-acting preparations such as nanometer preparations, microsphere preparations, liposomes and hydrogels. Background technique [0002] Neovascular glaucoma is a secondary glaucoma disease, mainly manifested in a large number of new blood vessels on the iris of the patient's eyes, showing the symptoms of glaucoma. There are many causes of neovascular glaucoma, but the most important causes of neovascular glaucoma are retinal vein occlusion and diabetic retinopathy. These two eye diseases can be secondary to neovascular glaucoma. The neovascular glaucoma ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more