Positron Emitter Radiation System

Abstract

The present invention analyzes the 11C fragments mainly produced by projectile fragmentation of a stable unidirectional and monoenergetic primary 11C ion beam in different decelerating materials, and has determined the most ideal target selection to obtain decelerated 11C ion beams in Highest possible beam quality for any energy and treatment range. The most desirable 11C generation target is hydrogen generation, preferably followed by a numerically controlled variable reducer including hydrogen-rich compounds such as polyethylene, to maximize the quality of the 11C ion beam.

Description

technical field [0001] Embodiments of the present invention relate generally to ion beam radiation, and in particular to the generation of positron emitting radiation beams useful for ionizing radiation therapy to increase their visibility in PET and PET-CT imaging. Background technique [0002] Precise monitoring of dose and response to tumors and surrounding normal tissues is a key topic in external beam radiation therapy. This is especially important for photoion therapy, since both their sharp depth dose distribution and steep lateral beam profile should be precisely positioned to make their application ideal for high physical and biological selectivity and normal tissue incidence is minimized. The high energy density delivered at the extremes of the particle range produces a sharp dose, with a maximum at the Bragg peak, which is important for localization within the patient's target volume. In photoion therapy, especially with ions heavier than hydrogen and helium, th...

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Problems solved by technology

However, background levels are high, and in different patient classes the Bragg peak is usually difficult to pinpoint with most PET cameras

Also, because the transient transfer from the input particle to the nuclei in the tissue is small and negligible, the activity due to the target fragmentation reaction can only be used to assess the position of the peak range of the ion beam.

Therefore, this method presents difficulties in establishing an exact correspondence between dose delivery and resulting activity, since the signal is low and the original activity is physically disused and more diffuse

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